Rucaparib (Rubraca) for ovarian cancer …

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Rucaparib (Rubraca) for ovarian cancer …
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Posted by:
Greg Lance – Watkins
Greg_L-W

eMail: Greg_L-W@BTconnect.com

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Hi,

Genetic outfit at work: Rucaparib (Rubraca) for ovarian cancer with deleterious BRCA mutation(s)

Posted on February 1, 2017
ovarian-cancer-02
February 01, 2017 – This is an announcement by the American Food & Drug Administration (FDA) who announced on December 19, 2016, that it granted accelerated approval to Rucaparib (Rubraca) to treat women with a certain type of ovarian cancer. Rucaparib (Rubraca) was approved for women with advanced ovarian cancer who have been treated with two or more chemotherapies and whose tumors have a specific gene mutation (deleterious BRCA) as identified by an FDA-approved companion diagnostic test.

genetic-mutation-01

Genetic Mutations Could Predict Patients Likely to Benefit from New Class of Cancer Drugs

“This approval is another example of the trend we are seeing in developing targeted agents to treat cancers caused by specific mutations in a patient’s genes,” said Richard Pazdur, M.D., director of the Office of Hematology and Oncology Products in the FDA’s Center for Drug Evaluation and Research and acting director of the FDA’s Oncology Center of Excellence. “Women with these gene abnormalities who have tried at least two chemotherapy treatments for their ovarian cancer now have an additional treatment option.”The National Cancer Institute estimates that 22,280 women will be diagnosed with ovarian cancer in 2016 and an estimated 14,240 will die of this disease. Approximately 15 to 20 percent of patients with ovarian cancer have a BRCA gene mutation.BRCA genes are involved with repairing damaged DNA and normally work to prevent tumor development. However, mutations of these genes may lead to certain cancers, including ovarian cancers. Rucaparib (Rubraca) is a poly ADP-ribose polymerase (PARP) inhibitor that blocks an enzyme involved in repairing damaged DNA. By blocking this enzyme, DNA inside the cancerous cells with damaged BRCA genes may be less likely to be repaired, leading to cell death and possibly a slow-down or stoppage of tumor growth.The FDA also approved the FoundationFocus CDxBRCA companion diagnostic for use with Rucaparib (Rubraca), which is the first next-generation-sequencing (NGS)-based companion diagnostic approved by the agency. The NGS test detects the presence of deleterious BRCA gene mutations in the tumor tissue of ovarian cancer patients. If one or more of the mutations are detected, the patient may be eligible for treatment with Rucaparib (Rubraca).The efficacy of Rucaparib (Rubraca) was studied in two, single-arm clinical trials involving 106 participants with BRCA-mutated advanced ovarian cancer who had been treated with two or more chemotherapy regimens. BRCA gene mutations were confirmed in 96 percent of tested trial participants with available tumor tissue using the FoundationFocus CDxBRCA companion diagnostic. The trials measured the percentage of participants who experienced complete or partial shrinkage of their tumors (overall response rate). Fifty-four percent of the participants who received Rucaparib (Rubraca) in the trials experienced complete or partial shrinkage of their tumors lasting a median of 9.2 months.In contrast to its efficacy, the safety profile of Rucaparib (Rubraca) is not without problems, however. Common side effects of Rucaparib (Rubraca) include nausea, fatigue, vomiting, low levels of red blood cells (anemia), abdominal pain, unusual taste sensation (dysgeusia), constipation, decreased appetite, diarrhea, low levels of blood platelets (thrombocytopenia) and trouble breathing (dyspnea). Rucaparib (Rubraca) is associated with serious risks, such as bone marrow problems (myelodysplastic syndrome), a type of cancer of the blood called acute myeloid leukemia and fetal harm.The agency approved Rucaparib (Rubraca) under its accelerated approval program, which allows approval of a drug to treat a serious or life-threatening disease or condition based on clinical data showing the drug has an effect on a surrogate (substitute) endpoint that is reasonably likely to predict clinical benefit. The sponsor is continuing to study this drug in patients with advanced ovarian cancer who have BRCA gene mutations and in patients with other types of ovarian cancer. The FDA also granted the Rucaparib (Rubraca) application breakthrough therapy designation and priority review status. Rucaparib (Rubraca) also received orphan drug designation, which provides incentives such as tax credits, user fee waivers and eligibility for exclusivity to assist and encourage the development of drugs intended to treat rare diseases.

To view the original of this article CLICK HERE
For more information on Rubraca CLICK HERE

Regards,
Greg_L-W.

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Posted by: Greg Lance-Watkins
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Cervical Cancer Can Be A Death Sentence Under 25 On The NHS …

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Cervical Cancer Can Be A Death Sentence Under 25 On The NHS …
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Posted by:
Greg Lance – Watkins
Greg_L-W

eMail: Greg_L-W@BTconnect.com

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Hi,

Lets not forget the bravery of Jade Goody (5 June 1981 – 22 March 2009) and how she made her fight against cervical cancer so very public right up until the day she died 8 years ago.

Jade Goody not only fought for survival, you will remember she had two little boys, but she fought for recognition of cervical cancer and the need for much younger women to be screened – the problem then was that women under 25 found it all but impossible to have screening, and Doctors seemed woefully ignorant of the risks for younger women.

Seems like little has changed and her efforts were ignored, once the media had no more mawkish picture stories to capitalise on!

Today I received the letter below – as cervical cancer killed yet another young woman because she couldn’t get screening under 25!

I am sure that you can help, either by seeking out petitions to sign or probably more valuably if you write to your political representatives and petition them yourself, on a regular basis, after all it could be your daughter, sister, girl friend or young wife who is condemned to death because she couldn’t get screening under 25!

If you are a young woman under 25 it could be you!

WHY NOT:
Print out this posting and provide the url sending it with a brief covering note to your MP, Regional Assembly Member and County Councillor – on a regular basis until the NHS law is changed to save young women too!

Just over 2 women die each day of cervical cancer. To be fair to the NHS most of those are in the 60+ age group. However surely teenage girls and young women under 25 should have automatic access to smear tests if they present with any of the symptoms of cervical cancer.

Is it the fact that cervical cancer cases are more prevalent in poorer areas that means it is neglected amongst young women? Do help campaign for a better response to early cervical cancer and help save these young women neglected by the system.

Greg,

My little sister Amber passed away last month after a long battle with cancer. She was only 25. 

She was worried when she started to get symptoms associated with cervical cancer – that was seven years ago. She asked her doctor for a smear test at least 10 times, but every time she was refused. Women in the UK aren’t offered cervical screenings until they turn 25. If my sister had been given what she asked for all those years ago, she might still be here now. 

I want Amber’s death to mean something. That’s why I am campaigning for Amber’s Law: an amendment that would let women under 25 get cervical cancer screening if they ask for it.

In the end Amber had to pay for a private screening in order to get diagnosed – but by then it was too late. She put up a good fight but the cancer had spread everywhere: her lymph nodes, her lungs and her throat. 

Currently women under 25 aren’t screened – the government say lowering the legal age of compulsory screening wouldn’t be productive and women under 25 rarely get this disease. But Amber’s story proves that some young women do get cervical cancer. I don’t think smear tests need to be mandatory for everyone, but if a woman asks her doctor for the test she shouldn’t be ignored. 

Amber was such a fighter. In her last week, when she was admitted to hospital for breathing difficulties, she fought off the paramedics to go upstairs and grab her makeup bag. She was determined keep fighting, she didn’t believe in giving up. Now she’s gone, I am going to be more like Amber and fight to raise her voice.

From
Josh Cliff

Josh Cliff set out to Petition the Government.

Make the cervical screening option available from 18 to high risk groups

The current age for cervical cancer screening in England is 25. If you are under 25 you aren’t allowed to have a screening due to the NHS guidelines, some Gps will send women under 25 for a smear if they have certain symptoms yet some won’t. This is why #Amberslaw needs to come in place. This means there would be a guideline through the NHS which allows ALL gps in any area of the U.K. To send people for smears under 25 if they have symptoms which are classed as alarming or high risk. 

Ambers Law

Any woman under the age of 25 who is not eligible for cervical cancer screening who goes to the doctors with any kind of problems in their lower half on 2 occasions will have the OPTION to have screening.

Amber went to the doctors multiple (I’m talking over 10 at least) times over the course of a few years and was constantly told ‘it’s your hormones’ ‘it’s a water infection’ ‘it’s your pill’ and when she asked for a screening they said no she was too young. We paid for her to get one private at the age of 21 and found she had cervical cancer that had been there for 2-4 years already. This over the course of 4 years spread to her lungs and her throat. Amber died at the age of 25, we lost a sister, daughter, grand daughter and an amazing friend to cancer because she was failed by the people who were meant to provide her care.

How would you feel if it was your sister or daughter? If you know deep down they could of been saved and still here today if they had the option for a screening at any age?

#AmberslawThere has been a couple of petitions been archived with no valid reason. Why not just lower the age? Why cant you help save young women?

Keeley McCormick started this petition with a single signature, and now has 201,319 supporters. Start a petition today to change something you care about.

Regards,
Greg_L-W.

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Posted by: Greg Lance-Watkins
tel: 44 (0)1594 – 528 337
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  13. I do NOT believe the IPCC Climate Propaganda re Anthropogenic Global Warming
  14. I AM strongly opposed to the subsidy or use of failed technologies eg. WIND TURBINES
  15. I AM IN FAVOUR of rapid research & development of NEW NUCLEAR technologies
  16. I see no evidence to trust POLITICIANS at any level or of any persuasion
  17. I do NOT believe in GODS singular or plural, Bronze Age or Modern
  18. I value the NHS as a HEALTH SERVICE NOT a Lifestyle support
  19. I believe in a DEATH PENALTY for serial or GBH rape.
  20. I believe in a DEATH PENALTY for serial, terrorist, mass or for pleasure murder.
  21. I believe in a DEATH PENALTY for serial gross child abuse including sexual.
  22. I do NOT trust or believe in armed police
  23. I do NOT believe in prolonging human life beyond reasonable expectation of sentient participatory intellectual existence
  24. I believe in EUTHENASIA under clearly defined & legal terms
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SEPSIS: The Stats, The Signs & Should be Treated ‘Like A Heart Attack’ …

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SEPSIS: The Stats, The Signs & Should be Treated ‘Like A Heart Attack‘ …
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Posted by:
Greg Lance – Watkins
Greg_L-W

eMail: Greg_L-W@BTconnect.com

~~~~~~~~~~#########~~~~~~~~~~

Hi,

did you know that although someone dies of cancer or heart disease about every 4 or 5 minutes in the UK. Although little heard of, someone dies of Sepsis about every 15 minutes, thats over 100 people a day who die of Sepsis!

Sepsis costs the NHS around £2,500,000 a day to treat or about £2 Billion a year!

The UK SEPSIS TRUST claims:

Every year in the UK there are 150,000 cases of Sepsis, resulting in a staggering 44,000 deaths – more than bowel, breast and prostate cancer combined.

UK incidence/ mortality data for SEPSIS
and comparators

37,000 annual deaths are derived from an extrapolated dataset provided to the UK Sepsis Trust by the Intensive Care National Audit and Research Centre (ICNARC) in 2006. The mortality rate for patients admitted to Critical Care with sepsis remains just under 35%, although this has fallen from 40% over the last 10 years.

102,000 cases seen annually in the UK comes from a conservative estimate of incidence derived from studies in other developed countries, including in Finland (Karlsson et al 2007), Spain (Blanco et al 2008) and Europe (Davies et al 2001). More recent estimates, including data to be published by the UK’s Health and Social Care Information Centre (HSCIC) and from Scandanavia (Henrikson et al 2015) and the U.S (Hall et al 2011), places the estimate closer to 200,000 cases per year with 60,000 deaths.

Costs

That each case of sepsis costs a healthcare system in a developed country €25,000 is derived from the European SOAP study (Vincent et al 2006): equating to about £2 billion annually for the UK.

COMPARE WITH Cardio Vascular Disease in the UK:

cvd-uk-stats-01

COMPARE with Cancer:

cancer-uk-stats-01

We hear constantly about the dangers of Heart Attacks and cancer but how often do we hear about Sepsis?

SEPSIS WARNING SIGNS

Sepsis, also referred to as blood poisoning or septicaemia, is a potentially life-threatening condition, triggered by an infection or injury.

In sepsis, the body’s immune system goes into overdrive as it tries to fight an infection.

This can reduce the blood supply to vital organs such as the brain, heart and kidneys.

Without quick treatment, sepsis can lead to multiple organ failure and death. 

Early symptoms of sepsis may include:

  • a high temperature (fever) or low body temperature
  • chills and shivering
  • a fast heartbeat
  • fast breathing

In some cases, symptoms of more severe sepsis or septic shock (when your blood pressure drops to a dangerously low level) develop soon after. These can include:

  • feeling dizzy or faint
  • a change in mental state, such as confusion or disorientation
  • diarrhoea
  • nausea and vomiting
  • slurred speech
  • severe muscle pain
  • severe breathlessness
  • less urine production than normal (for example, not urinating for a day)
  • cold, clammy and pale or mottled skin
  • loss of consciousness

Severe sepsis and septic shock are medical emergencies. If you think that you or someone in your care has one of these conditions, call 999 and ask for an ambulance.

Source: NHS Choices  

To DOWNLOAD a Poster

for your Office, School, Notice Board, Club. Work or for a friend just CLICK HERE

Treat sepsis ‘the same as heart attacks’

To read more CLICK HERE

To GO TO The UK SEPSIS TRUST Home Page CLICK HERE

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
Posted by: Greg Lance-Watkins
tel: 44 (0)1594 – 528 337
Calls from ‘Number Withheld’ phones Are Blocked

All unanswered messages are recorded.
Leave your name & a UK land line number & I will return your call.

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Documents, Essays & Treaties: CLICK HERE
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Health Blog.: CLICK HERE
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Christopher Story: CLICK HERE
Des Watkins DFC; CdeG: CLICK HERE/
Hollie Greig etc.: CLICK HERE
Psycheocracy: CLICK HERE
The McCann Case: CLICK HERE
The Speculative Society of Edinburgh: CLICK HERE
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Stolen Kids Blogs with links:
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NB:
  1. I NEVER post anonymously on the internet
  2. ALL MY BLOGS & WEB SITES are clearly sourced to me
  3. I do NOT use an obfuscated eMail address to hide behind
  4. I do NOT use or bother reading FaceBook
  5. I DO have a Voice Mail Message System
  6. I ONLY GUARANTEE to answer identifiable eMails
  7. I ONLY GUARANTEE to phone back identifiable UK Land Line Messages
  8. I do NOT accept phone calls from witheld numbers
  9. I Regret due to BT in this area I have a rubbish Broadband connection
  10. I AM opposed to British membership of The EU
  11. I AM opposed to Welsh, Scottish or English Independence within an interdependent UK
  12. I am NOT a WARMIST
  13. I do NOT believe the IPCC Climate Propaganda re Anthropogenic Global Warming
  14. I AM strongly opposed to the subsidy or use of failed technologies eg. WIND TURBINES
  15. I AM IN FAVOUR of rapid research & development of NEW NUCLEAR technologies
  16. I see no evidence to trust POLITICIANS at any level or of any persuasion
  17. I do NOT believe in GODS singular or plural, Bronze Age or Modern
  18. I value the NHS as a HEALTH SERVICE NOT a Lifestyle support
  19. I believe in a DEATH PENALTY for serial or GBH rape.
  20. I believe in a DEATH PENALTY for serial, terrorist, mass or for pleasure murder.
  21. I believe in a DEATH PENALTY for serial gross child abuse including sexual.
  22. I do NOT trust or believe in armed police
  23. I do NOT believe in prolonging human life beyond reasonable expectation of sentient participatory intellectual existence
  24. I believe in EUTHENASIA under clearly defined & legal terms
  25. I try to make every effort to NOT infringe copyrights in any commercial way & make all corrections of fact brought to my attention by an identifiable individual

Please Be Sure To
.Follow Greg_LW on Twitter.

Re-TWEET my Twitterings

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~~~~~~~~~~#########~~~~~~~~~~

US Fund Managers Betting Against Trump On Obamacare …

~~~~~~~~~~#########~~~~~~~~~~
US Fund Managers Betting Against Trump On Obamacare …
~~~~~~~~~~#########~~~~~~~~~~

Posted by:
Greg Lance – Watkins
Greg_L-W

eMail: Greg_L-W@BTconnect.com

~~~~~~~~~~#########~~~~~~~~~~

Hi,

U.S. fund managers betting Trump fails to rewrite Obamacare

By David Randall | NEW YORK

Some prominent U.S. fund managers are betting that former President Barack Obama’s signature healthcare law will not undergo the widespread changes that President Donald Trump promised on the campaign trail.

Portfolio managers from Fidelity, Gamco, Thornburg and other large firms say they see the broad outlines of the Affordable Care Act – commonly known as Obamacare – remaining intact despite Trump’s signing of an executive order on Friday, his first day in office, that sought to weaken it.

As a result, these fund managers say they are buying shares of hospitals, health insurance companies and biotech firms they see as unfairly hit by political uncertainty.

“They may do enough to try to rebrand it as Trumpcare, but I just don’t think it will be that dramatically different from what we have today,” said Jeff Jonas, a portfolio manager at Gamco Investors in Rye, New York, who said he has been adding to his position in hospital and nursing center company Kindred Healthcare Inc and large health insurance companies.

“The executive order itself was very vague, and it’s a little hard to say at this point what actual effect it will have,” he said.

Trump’s order directs government departments to “waive, defer, grant exemptions from, or delay the implementation” of provisions of the law that imposed fiscal burdens on states, companies or individuals, but provides no details.

HOSPITAL STOCKS GAINING

Investors overall still look hesitant to buy healthcare stocks, with fund flows to the iShares US Healthcare ETF, a widely held exchange traded fund that tracks the healthcare industry, falling 4.8 percent in the week ending Jan. 11, according to Lipper data.

Healthcare stocks fell swiftly after Trump was elected on Nov. 8, and have underperformed since. The S&P 500 healthcare sector has gained 2 percent since Election Day, compared with a 6.3 percent rise in the S&P 500 over the same time.

But hospital stocks such as HCA Holdings Inc have outperformed since the start of January on signs that Republicans plan to replace the Affordable Care Act at the same time they repeal it. Shares of HCA are up 7.9 percent since the start of the year, compared with a 1.2 percent gain in the S&P 500, and are trading slightly higher than they were on Election Day.

Although repealing the law requires only a majority in the Senate, replacing it would require at least 60 votes in the Senate, meaning that Republicans would have to win some Democratic support. As a result, fund managers said they expect only incremental changes.

A repeal without a replacement could put pressure on hospitals by rescinding the Medicaid expansion and individual subsidies, prompting more individuals to go without insurance and be unable to pay their hospital bills.

Representative Tom Price, Trump’s nominee for health secretary, said in a hearing Wednesday that the administration will initially focus on individual health plans sold on exchanges and is not interested in “pulling the rug out on anybody,” though he said it would also focus on Medicaid.

Some Republicans in Congress have been pushing for an outright repeal in order to give states more control of their healthcare programs. The House and Senate passed resolutions to have draft legislation that would repeal the law ready by Jan. 27. Other Republican senators have proposed that states have the option remain in the Obamacare insurance program.

NOT “A WHOLE LOT OF DISRUPTION”

Eddie Yoon, portfolio manager of the $6.1 billion Fidelity Select Heath Care fund in Boston, has not changed his holdings since the election because he does not see large changes coming.

He said he remains bullish on the medical device and biotech industries because both do not look like they would be significantly affected by any of the Republican healthcare proposals. He expects the moratorium on a tax on medical device sales, due to expire at the end of 2017, will be extended, and that controls on drug prices floated by Trump are unlikely to be enacted.

“I don’t think the new administration wants to get bogged down in healthcare and they want to move on to immigration and tax reform and bigger policy items,” said Yoon. “I don’t anticipate that there will be a whole lot of disruption.”

Biotech may also benefit if Congress passes legislation that cuts the taxes companies pay on profits earned overseas, leaving pharmaceutical companies flush and ushering in a wave of mergers and acquisitions, he said.

The Nasdaq Biotechnlogy Index is up 3.8 percent since the beginning of the year after falling more than 20 percent last year.

Connor Browne, a portfolio manager with the $889 million Thornburg Value fund in Santa Fe, New Mexico, said he added a position in biotech company Seattle Genetics Inc in late December. He also has been adding to his position in medical device makers in anticipation that little will be done to change the law, meaning that millions of Americans will still have insurance that will help pay for devices.

“While it hasn’t so far paid to underestimate Donald Trump, it sure seems like we might be seeing indications that he doesn’t understand how hard it will be to get legislation done,” Browne said.

To view the original of this article CLICK HERE

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
Posted by: Greg Lance-Watkins
tel: 44 (0)1594 – 528 337
Calls from ‘Number Withheld’ phones Are Blocked

All unanswered messages are recorded.
Leave your name & a UK land line number & I will return your call.

‘e’Mail Address: Greg_L-W@BTconnect.com

DO MAKE USE of LINKS,
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&
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Also:

ABOUT ME, Details & Links: CLICK HERE
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General ‘Stuff’: http://GL-W.com
Leave-The-EU Referendum & BreXit Process CLICK HERE
Documents, Essays & Treaties: CLICK HERE
The Hamlet of Stroat: CLICK HERE
Data & The Study of a Wind Turbine Application: CLICK HERE
Health Blog.: CLICK HERE
Chepstow Chat: CLICK HERE
Christopher Story: CLICK HERE
Des Watkins DFC; CdeG: CLICK HERE/
Hollie Greig etc.: CLICK HERE
Psycheocracy: CLICK HERE
The McCann Case: CLICK HERE
The Speculative Society of Edinburgh: CLICK HERE
Stolen Kids, Dunblane: CLICK HERE
Stolen Kids, Bloggers: CLICK HERE
Views I respect & almost Totally Share: CLICK HERE
A Concept of Governance Worthy of Developement: CLICK HERE

Skype: GregL-W

TWITTER: @Greg_LW

Stolen Kids Blogs with links:
http://StolenKids-Bloggers.Blogspot.com
Stolen Oyster with links:
http://StolenOyster-Bloggers.Blogspot.com
Stolen Trust with links:
http://StolenTrust-Bloggers.Blogspot.com
Stolen Childhood with links:
http://StolenChildhood-Bloggers.Blogspot.com
NB:
  1. I NEVER post anonymously on the internet
  2. ALL MY BLOGS & WEB SITES are clearly sourced to me
  3. I do NOT use an obfuscated eMail address to hide behind
  4. I do NOT use or bother reading FaceBook
  5. I DO have a Voice Mail Message System
  6. I ONLY GUARANTEE to answer identifiable eMails
  7. I ONLY GUARANTEE to phone back identifiable UK Land Line Messages
  8. I do NOT accept phone calls from witheld numbers
  9. I Regret due to BT in this area I have a rubbish Broadband connection
  10. I AM opposed to British membership of The EU
  11. I AM opposed to Welsh, Scottish or English Independence within an interdependent UK
  12. I am NOT a WARMIST
  13. I do NOT believe the IPCC Climate Propaganda re Anthropogenic Global Warming
  14. I AM strongly opposed to the subsidy or use of failed technologies eg. WIND TURBINES
  15. I AM IN FAVOUR of rapid research & development of NEW NUCLEAR technologies
  16. I see no evidence to trust POLITICIANS at any level or of any persuasion
  17. I do NOT believe in GODS singular or plural, Bronze Age or Modern
  18. I value the NHS as a HEALTH SERVICE NOT a Lifestyle support
  19. I believe in a DEATH PENALTY for serial or GBH rape.
  20. I believe in a DEATH PENALTY for serial, terrorist, mass or for pleasure murder.
  21. I believe in a DEATH PENALTY for serial gross child abuse including sexual.
  22. I do NOT trust or believe in armed police
  23. I do NOT believe in prolonging human life beyond reasonable expectation of sentient participatory intellectual existence
  24. I believe in EUTHENASIA under clearly defined & legal terms
  25. I try to make every effort to NOT infringe copyrights in any commercial way & make all corrections of fact brought to my attention by an identifiable individual

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~~~~~~~~~~#########~~~~~~~~~~

Big Pharma Under Attack as Europe backs biosimilar versions of drugs …

~~~~~~~~~~#########~~~~~~~~~~
 Big Pharma Under Attack as Europe backs biosimilar versions of drugs …
~~~~~~~~~~#########~~~~~~~~~~

Posted by:
Greg Lance – Watkins
Greg_L-W

eMail: Greg_L-W@BTconnect.com

~~~~~~~~~~#########~~~~~~~~~~

Hi,

Europe’s oncologists back biosimilar versions of cancer drugs

Europe’s leading association of oncologists has thrown its weight behind cheaper copycat versions of biotech cancer drugs that have lost patent protection, saying they are effective and affordable.

Off-patent chemical medicines have for decades been copied with precision and sold as cheap generic versions, but drug regulators have only over recent years embraced copycat versions of complex biological drugs, known as biosimilars.

Even though biotech drugs, which are proteins made from genetically-modified cells, cannot be exactly replicated, biosimilars have been shown to be equivalent in terms of effectiveness and side effects.

“Biosimilars are must-have weaponry in financially sustaining healthcare systems on a global scale as well as significantly improving outcomes for an increasing number of patients throughout Europe and the rest of the world,” ESMO President Professor Fortunato Ciardiello said in a statement.

ESMO added that price discounts for biosimilars of 20 to 40 percent could be reached in Europe, with potential savings for healthcare systems of 50–100 billion euros ($53-$107 billion) by 2020.

Europe has been in the lead over the United States in opening up regulatory pathways for biosimilars.

The first biosimilar versions of cancer drugs are expected to reach the market in Europe this year, with Amgen Inc and Allergan Plc seeking EU approval of their version of Roche Holding AG’s blockbuster cancer treatment Avastin.

“Biosimilars are an excellent opportunity to have good, valid drug options that improve the sustainability and affordability of cancer treatment in various countries,” ESMO said, also publishing a paper with recommendations on how doctors should handle them.

To view the original of this article CLICK HERE

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
Posted by: Greg Lance-Watkins
tel: 44 (0)1594 – 528 337
Calls from ‘Number Withheld’ phones Are Blocked

All unanswered messages are recorded.
Leave your name & a UK land line number & I will return your call.

‘e’Mail Address: Greg_L-W@BTconnect.com

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Data & The Study of a Wind Turbine Application: CLICK HERE
Health Blog.: CLICK HERE
Chepstow Chat: CLICK HERE
Christopher Story: CLICK HERE
Des Watkins DFC; CdeG: CLICK HERE/
Hollie Greig etc.: CLICK HERE
Psycheocracy: CLICK HERE
The McCann Case: CLICK HERE
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Stolen Kids, Dunblane: CLICK HERE
Stolen Kids, Bloggers: CLICK HERE
Views I respect & almost Totally Share: CLICK HERE
A Concept of Governance Worthy of Developement: CLICK HERE

Skype: GregL-W

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Stolen Kids Blogs with links:
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Stolen Childhood with links:
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NB:
  1. I NEVER post anonymously on the internet
  2. ALL MY BLOGS & WEB SITES are clearly sourced to me
  3. I do NOT use an obfuscated eMail address to hide behind
  4. I do NOT use or bother reading FaceBook
  5. I DO have a Voice Mail Message System
  6. I ONLY GUARANTEE to answer identifiable eMails
  7. I ONLY GUARANTEE to phone back identifiable UK Land Line Messages
  8. I do NOT accept phone calls from witheld numbers
  9. I Regret due to BT in this area I have a rubbish Broadband connection
  10. I AM opposed to British membership of The EU
  11. I AM opposed to Welsh, Scottish or English Independence within an interdependent UK
  12. I am NOT a WARMIST
  13. I do NOT believe the IPCC Climate Propaganda re Anthropogenic Global Warming
  14. I AM strongly opposed to the subsidy or use of failed technologies eg. WIND TURBINES
  15. I AM IN FAVOUR of rapid research & development of NEW NUCLEAR technologies
  16. I see no evidence to trust POLITICIANS at any level or of any persuasion
  17. I do NOT believe in GODS singular or plural, Bronze Age or Modern
  18. I value the NHS as a HEALTH SERVICE NOT a Lifestyle support
  19. I believe in a DEATH PENALTY for serial or GBH rape.
  20. I believe in a DEATH PENALTY for serial, terrorist, mass or for pleasure murder.
  21. I believe in a DEATH PENALTY for serial gross child abuse including sexual.
  22. I do NOT trust or believe in armed police
  23. I do NOT believe in prolonging human life beyond reasonable expectation of sentient participatory intellectual existence
  24. I believe in EUTHENASIA under clearly defined & legal terms
  25. I try to make every effort to NOT infringe copyrights in any commercial way & make all corrections of fact brought to my attention by an identifiable individual

Please Be Sure To
.Follow Greg_LW on Twitter.

Re-TWEET my Twitterings

& Publicise My Blogs
To Spread The Facts World Wide
~~~~~~~~~~#########~~~~~~~~~~

Early Diagnosis of Cancer In USA Increased By Obamacare …

~~~~~~~~~~#########~~~~~~~~~~
Early Diagnosis of Cancer In USA Increased By Obamacare …
~~~~~~~~~~#########~~~~~~~~~~

Posted by:
Greg Lance – Watkins
Greg_L-W

eMail: Greg_L-W@BTconnect.com

~~~~~~~~~~#########~~~~~~~~~~

Hi,

Researchers credit Obamacare with helping find early-stage cancer

By Ronnie Cohen

(Reuters Health) – The Affordable Care Act likely extended the lives of thousands of seniors who took advantage of free screening exams and were diagnosed with treatable, early-stage colorectal cancer, a new study suggests.

“I think the prevention-related provisions of the Affordable Care Act helped to detect cancer at earlier and more treatable stages and eventually will save lives,” said senior author Nengliang “Aaron” Yao, a health-policy professor at the University of Virginia School of Medicine in Charlottesville.

Before the Affordable Care Act, often called Obamacare, took effect, people ages 65 and older who were insured under Medicare had to pay $275 for colonoscopies, the report in Health Affairs says.

The Affordable Care Act (ACA) directed that colonoscopies be offered for free.

From 2011, when the law took effect, until 2013, an additional 8,400 seniors, or 8 percent more than before, were diagnosed with early-stage colorectal cancer, researchers estimated.

“The study does a very nice job of showing that when you remove financial barriers to healthcare, health improves,” said Dr. Cary Gross, a professor at the Yale School of Medicine, in New Haven, Connecticut who was not involved in the study. “When the Affordable Care Act granted more generous coverage, we were more likely to detect cancer at an earlier stage.”

“This shows that when it comes to creating a new healthcare plan, the devil’s in the details, and policymakers need to look at things like how will the proposed changes affect cancer screening,” Gross said in a phone interview.

Colorectal cancer is the second leading cause of U.S. cancer-related deaths, according to the U.S. Centers for Disease Control and Prevention, or CDC. Nearly 52,000 Americans died from colorectal cancer in 2013.

Though research shows that screening reduces the risk of dying from colorectal cancer, only 25 percent of uninsured people and 60 percent of insured people had been screened as recommended, a 2015 CDC study showed.

Both Yao and Gross would like President Donald Trump and Republican lawmakers, who have pledged to repeal the ACA, to consider the ramifications of the new study before ruling on future healthcare legislation.

“I’m very concerned that policymakers who are trying to save money by not covering cancer-prevention services are being penny-wise and pound-foolish,” Gross said. “They may save money today, but we will be paying a lot more taking care of patients with metastatic cancer down the road.”

“I’m worried on behalf of our patients and our communities that these great strides we’ve made against cancer will evaporate if the important provisions of the Affordable Care Act, which ensure that patients can access cancer screening services without additional costs, are taken away,” he said.

In the new study, researchers examined data from 18 cancer registries across the U.S. They found no change in the number of Medicare early-stage cancer diagnoses for breast cancer between the period before Obamacare, from 2008 until 2010, until the period after, from 2011 until 2013.

Mammography to screen for breast cancer became free for Medicare patients under the ACA, but before that, it cost just $9 – a significantly smaller financial barrier than the $275 cost of a colonoscopy, Yao said in a phone interview.

In addition, breast cancer screening had been marketed more successfully than colorectal screening before the ACA was enacted, he said.

Gross noted that colonoscopies can actually prevent cancer, because doctors can remove polyps during the procedure, whereas mammograms only allow doctors to see growths in the breast.

The U.S. Preventive Services Task Force found convincing evidence that colorectal cancer screening substantially reduces deaths in adults between 50 and 75 years old, it said last year. The task force recommended screening with colonoscopy, stool analyses or flexible sigmoidoscopy combined with a fecal-occult blood test.

The new study could not determine the impact of free colonoscopies on metastatic colorectal cancer rates or mortality from colorectal cancer. Gross urged follow-up studies examining those numbers after they become available.

To view the original of this article CLICK HERE

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
Posted by: Greg Lance-Watkins
tel: 44 (0)1594 – 528 337
Calls from ‘Number Withheld’ phones Are Blocked

All unanswered messages are recorded.
Leave your name & a UK land line number & I will return your call.

‘e’Mail Address: Greg_L-W@BTconnect.com

DO MAKE USE of LINKS,
>SEARCH<
&
>Side Bars<
&
The Top Bar >PAGES<

Also:

ABOUT ME, Details & Links: CLICK HERE
Accuracy & Copyright Statement: CLICK HERE 
UKIP Its ASSOCIATES & DETAILS: CLICK HERE 
Summary & archive, facts & comments on Ukip: http://Ukip-vs-EUkip.com
General ‘Stuff’: http://GL-W.com
Leave-The-EU Referendum & BreXit Process CLICK HERE
Documents, Essays & Treaties: CLICK HERE
The Hamlet of Stroat: CLICK HERE
Data & The Study of a Wind Turbine Application: CLICK HERE
Health Blog.: CLICK HERE
Chepstow Chat: CLICK HERE
Christopher Story: CLICK HERE
Des Watkins DFC; CdeG: CLICK HERE/
Hollie Greig etc.: CLICK HERE
Psycheocracy: CLICK HERE
The McCann Case: CLICK HERE
The Speculative Society of Edinburgh: CLICK HERE
Stolen Kids, Dunblane: CLICK HERE
Stolen Kids, Bloggers: CLICK HERE
Views I respect & almost Totally Share: CLICK HERE
A Concept of Governance Worthy of Developement: CLICK HERE

Skype: GregL-W

TWITTER: @Greg_LW

Stolen Kids Blogs with links:
http://StolenKids-Bloggers.Blogspot.com
Stolen Oyster with links:
http://StolenOyster-Bloggers.Blogspot.com
Stolen Trust with links:
http://StolenTrust-Bloggers.Blogspot.com
Stolen Childhood with links:
http://StolenChildhood-Bloggers.Blogspot.com
NB:
  1. I NEVER post anonymously on the internet
  2. ALL MY BLOGS & WEB SITES are clearly sourced to me
  3. I do NOT use an obfuscated eMail address to hide behind
  4. I do NOT use or bother reading FaceBook
  5. I DO have a Voice Mail Message System
  6. I ONLY GUARANTEE to answer identifiable eMails
  7. I ONLY GUARANTEE to phone back identifiable UK Land Line Messages
  8. I do NOT accept phone calls from witheld numbers
  9. I Regret due to BT in this area I have a rubbish Broadband connection
  10. I AM opposed to British membership of The EU
  11. I AM opposed to Welsh, Scottish or English Independence within an interdependent UK
  12. I am NOT a WARMIST
  13. I do NOT believe the IPCC Climate Propaganda re Anthropogenic Global Warming
  14. I AM strongly opposed to the subsidy or use of failed technologies eg. WIND TURBINES
  15. I AM IN FAVOUR of rapid research & development of NEW NUCLEAR technologies
  16. I see no evidence to trust POLITICIANS at any level or of any persuasion
  17. I do NOT believe in GODS singular or plural, Bronze Age or Modern
  18. I value the NHS as a HEALTH SERVICE NOT a Lifestyle support
  19. I believe in a DEATH PENALTY for serial or GBH rape.
  20. I believe in a DEATH PENALTY for serial, terrorist, mass or for pleasure murder.
  21. I believe in a DEATH PENALTY for serial gross child abuse including sexual.
  22. I do NOT trust or believe in armed police
  23. I do NOT believe in prolonging human life beyond reasonable expectation of sentient participatory intellectual existence
  24. I believe in EUTHENASIA under clearly defined & legal terms
  25. I try to make every effort to NOT infringe copyrights in any commercial way & make all corrections of fact brought to my attention by an identifiable individual

Please Be Sure To
.Follow Greg_LW on Twitter.

Re-TWEET my Twitterings

& Publicise My Blogs
To Spread The Facts World Wide
~~~~~~~~~~#########~~~~~~~~~~

Turmeric / Curcumin & Lemon as a Morning Drink is CLAIMED to work wonders

~~~~~~~~~~#########~~~~~~~~~~
Turmeric / Curcumin & Lemon as a Morning Drink is CLAIMED to work wonders …
~~~~~~~~~~#########~~~~~~~~~~

Posted by:
Greg Lance – Watkins
Greg_L-W

eMail: Greg_L-W@BTconnect.com

~~~~~~~~~~#########~~~~~~~~~~

Hi,

Turmeric / Curcumin & Lemon as a Morning Drink is CLAIMED to work wonders controlling Inflammation!

Before moving on to discuss Turmeric, Lemon & Cucumin regular readers of this web site will appreciate that I am neither medicaloly qualified nor am I offering advice as such. Further I rarely stray far away from reportage of facts and factually based opinions – almost never venturing into the minefield of alternative medicines where all too many are money spinning quackery!
Before considering ANY alternative medicaments or treatments I strongly advise both common sense and caution and if you have ANY doubts consult your regular Physician who is both trained and insured to responsibly provide his or her considered professional opinion.
That said I do believe that there are many areas that can help, not least of all, your general health and many which may well aid with specific conditions – in simple terms consider the damage that can be done with inadequate or junk foods and the harm that is caused by failure to drink enough and control the intake of dangerous chemicals like alcohol or smoking – both of which are crippling our NHS not to mention far outstripping Class A drugs as a cost on both life and the NHS budget!
Astonishingly the not unusual average intake of sugar and saturated fats also bears a heavy responsibility for the progressive sabotage of not only our NHS but also our Health as a nation!
Therefore perhaps you should consider the following articles on Lemon, Turmeric & Curcumin & the other ingredients, mentioned in this article, as a starting point for your own research and consideration, as with the ‘Nature Cures – Asian’ CLICK HERE to which I have linked in the listed >PAGES< below the header on this web site.

fightinflammationturmericlemon_640x359

 

Starting the day with your morning routine may suit your needs just fine. A bit of yoga, maybe meditation, a shower, a healthy breakfast with organic coffee, and then out the door. Does this sound familiar? If so, your morning routine is already exceptional. But we have a mighty elixir that can compliment your regimen wonderfully.

You may have heard that warm lemon water will get those pipes working in the morning and optimize your health. You may even drink warm lemon water with Himalayan salt, or warm lemon water with honey in the morning. However, have you heard of warm lemon water combined with honey, cinnamon, and the most essential ingredient to this morning elixir, turmeric? If you have yet to try this one, you may be missing out on an excellent way to begin your day. All-natural lemon and turmeric are especially powerful ingredients that boast a wealth of beneficial properties.

Lemons offer a tasty, tart flavor with many health-promoting properties. According to a study published in the Chemistry Central Journal (2015), lemons possess a treasure trove of natural metabolites. The study authors state, “Citrus fruits exhibit plentiful bioactivities including antioxidant, anti-inflammatory, anti-cancer, antimicrobial and anti-allergy activities, as well as cardiovascular effect, neuroprotective effect, hepatoprotective effect, obesity control, etc.” Lemons are indeed a healthy ingredient to enjoy at the beginning of the day. However, when you couple lemon with turmeric, your health and wellness benefits increase significantly.

Turmeric (Curcuma longa) is a yellow-orange spice that is part of the ginger family. Native to tropical South Asia, turmeric is well known in traditional Asian medicine and cuisine. More recently, its health benefits have been recognized in Western medicine. According to a study published in the Journal of Nephropathology (2012), “Turmeric, a neglected Asian traditional drug might reemerge as remedy and/or preventive tool for various illnesses including different type of cancers, obesity, type-2 diabetes, hyperlipidemia, hypertension, CKD [chronic kidney disease] and ESRD [end stage renal disease], which are steadily increasing globally, claiming many lives and tremendous amount of resources worldwide.”

One active ingredient in turmeric, curcumin, has been the focus of several academic studies.

Curcumin may alleviate inflammation: According to research from the Department of Stomatology at the University of California, San Francisco, curcumin possesses anti-inflammatory properties. The research, published in the Journal of Alternative and Complementary Medicine (2004), found that curcumin, “may exert its anti-inflammatory activity by inhibition of a number of different molecules that play a role in inflammation.”

fightinflammationturmericlemon_640x359Curcumin’s anticancer potential: Curcumin may play a vital role in cancer prevention, according to a study published in BioMed Research International (2014). Previous research has highlighted curcumin’s antioxidant, antibacterial and antitumor properties, according to the study, which concluded, “Curcumin, a vital constituent of the spice turmeric, is an alternative approach in the prevention of cancer.”

Therapeutic applications of curcumin: According to a review study published in the AAPS Journal (2013), “curcumin has shown therapeutic potential against a number of human diseases,” including multiple types of cancer, inflammatory bowel disease, irritable bowel syndrome, arthritis, peptic ulcers, psoriasis, H. pylori infection, Alzheimer’s disease, acute coronary syndrome, atherosclerosis, diabetes, and respiratory tract infections.

The Turmeric and Lemon Morning Elixir
1 serving
Prep Time- 5 minutes
Cook Time- no cooking

Ingredients
What you’ll need…
1/2 of a lemon, squeezed for juice
1/4 – 1/2 tsp turmeric
1/2 tsp honey
1/4 tsp cinnamon powder
1 cup warm water, and/or coconut milk (the coconut milk adds healthy fats, and helps absorption of turmeric)

How to make it…

Mix the lemon juice, turmeric and honey into your cup of warm water or milk. You will want to stir these ingredients well. Add cinnamon on top and continue to stir your morning elixir as you drink it — this will ensure that the turmeric does not settle at the bottom of your cup.

Turmeric with its main active ingredient, curcumin, may be that one healthy addition to your morning routine you’ve been looking for, and can help you fight inflammation in your body.  I enjoy this elixir nearly every morning with fruit, which adds a sweet, delicious twist.

What healthy alternatives get your morning off to a perfect start?

To view the original article CLICK HERE

Note from The Nutrition Watchdog:

This Lemon, Turmeric, Coconut Oil Tea Will Relieve Your Pain FAST

It’s a great idea to use all-natural remedies wherever possible. After all, the possible side effects of over-the-counter pain relievers can be frightening. Long-term use can even be dangerous. That’s why being able to quickly whip up this pain relief tea is a great comfort. With this recipe, I know I am treating my pain in a natural way that is good for my body. There are many options out there on the market, but using a natural remedy is much more appealing.

The ingredients in this pain relief tea are powerful. There are thousands of great studies on turmeric and the amazing benefits it can give the body. Turmeric has been shown to be effective in treating stomach ulcers, kidney inflammation, Crohn’s disease, osteoarthritis and more. Lemons can help flush away toxins and enhance immune health. Coconut oil is antibacterial, antiviral and antifungal to help prevent the spread of viruses. I could go on and on, but let’s try making this pain relief tea so you feel better! 

Ingredients For Pain Relief Tea

  • 1 tsp turmeric
  • 1 tsp lemon juice
  • 1/2 tsp ginger powder
  • A pinch of cayenne pepper
  • 4 turns of fresh ground pepper
  • 2 tsp coconut oil
  • 2 tsp honey

Instructions

1. Gather all ingredients and mug for pain relief tea.

2. Measure out the ingredients.

3. Place turmeric, cayenne, black pepper and ginger in the mug.

4. Pour hot water over the spices in the mug.

5. Add coconut oil and honey. Stir or whisk to combine.

6. Drink pain relief tea right away, stirring between sips to keep spices mixed.

To view the original of this article CLICK HERE

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
Posted by: Greg Lance-Watkins
tel: 44 (0)1594 – 528 337
Calls from ‘Number Withheld’ phones Are Blocked

All unanswered messages are recorded.
Leave your name & a UK land line number & I will return your call.

‘e’Mail Address: Greg_L-W@BTconnect.com

DO MAKE USE of LINKS,
>SEARCH<
&
>Side Bars<
&
The Top Bar >PAGES<

Also:

ABOUT ME, Details & Links: CLICK HERE
Accuracy & Copyright Statement: CLICK HERE 
UKIP Its ASSOCIATES & DETAILS: CLICK HERE 
Summary & archive, facts & comments on Ukip: http://Ukip-vs-EUkip.com
General ‘Stuff’: http://GL-W.com
Leave-The-EU Referendum & BreXit Process CLICK HERE
Documents, Essays & Treaties: CLICK HERE
The Hamlet of Stroat: CLICK HERE
Data & The Study of a Wind Turbine Application: CLICK HERE
Health Blog.: CLICK HERE
Chepstow Chat: CLICK HERE
Christopher Story: CLICK HERE
Des Watkins DFC; CdeG: CLICK HERE/
Hollie Greig etc.: CLICK HERE
Psycheocracy: CLICK HERE
The McCann Case: CLICK HERE
The Speculative Society of Edinburgh: CLICK HERE
Stolen Kids, Dunblane: CLICK HERE
Stolen Kids, Bloggers: CLICK HERE
Views I respect & almost Totally Share: CLICK HERE
A Concept of Governance Worthy of Developement: CLICK HERE

Skype: GregL-W

TWITTER: @Greg_LW

Stolen Kids Blogs with links:
http://StolenKids-Bloggers.Blogspot.com
Stolen Oyster with links:
http://StolenOyster-Bloggers.Blogspot.com
Stolen Trust with links:
http://StolenTrust-Bloggers.Blogspot.com
Stolen Childhood with links:
http://StolenChildhood-Bloggers.Blogspot.com
NB:
  1. I NEVER post anonymously on the internet
  2. ALL MY BLOGS & WEB SITES are clearly sourced to me
  3. I do NOT use an obfuscated eMail address to hide behind
  4. I do NOT use or bother reading FaceBook
  5. I DO have a Voice Mail Message System
  6. I ONLY GUARANTEE to answer identifiable eMails
  7. I ONLY GUARANTEE to phone back identifiable UK Land Line Messages
  8. I do NOT accept phone calls from witheld numbers
  9. I Regret due to BT in this area I have a rubbish Broadband connection
  10. I AM opposed to British membership of The EU
  11. I AM opposed to Welsh, Scottish or English Independence within an interdependent UK
  12. I am NOT a WARMIST
  13. I do NOT believe the IPCC Climate Propaganda re Anthropogenic Global Warming
  14. I AM strongly opposed to the subsidy or use of failed technologies eg. WIND TURBINES
  15. I AM IN FAVOUR of rapid research & development of NEW NUCLEAR technologies
  16. I see no evidence to trust POLITICIANS at any level or of any persuasion
  17. I do NOT believe in GODS singular or plural, Bronze Age or Modern
  18. I value the NHS as a HEALTH SERVICE NOT a Lifestyle support
  19. I believe in a DEATH PENALTY for serial or GBH rape.
  20. I believe in a DEATH PENALTY for serial, terrorist, mass or for pleasure murder.
  21. I believe in a DEATH PENALTY for serial gross child abuse including sexual.
  22. I do NOT trust or believe in armed police
  23. I do NOT believe in prolonging human life beyond reasonable expectation of sentient participatory intellectual existence
  24. I believe in EUTHENASIA under clearly defined & legal terms
  25. I try to make every effort to NOT infringe copyrights in any commercial way & make all corrections of fact brought to my attention by an identifiable individual

Please Be Sure To
.Follow Greg_LW on Twitter.

Re-TWEET my Twitterings

& Publicise My Blogs
To Spread The Facts World Wide
~~~~~~~~~~#########~~~~~~~~~~