A ROUNDUP + Velindre – appt.: Dr. Lester re.: MRI Results – 12-Aug-2011 – 15:15

A ROUNDUP + Velindre – appt.: Dr. Lester re.: MRI Results – 12-Aug-2011 – 15:15

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Hi,

well a whole week since my last Radio Therapy and I still seem OK!

I was on time for a change so not driving hell for leather.

As I thought Jason Lester is still on holiday and was right so I saw his Registrar Rachel Micalles – I am pleased to say the MRI scan has for certain shown up no signs of mets. in the spine anywhere nor in the sacrum or seemingly the pelvis so that is the good news!

The not so good news is that I do have fairly notable degenerative disease in the spine – I offered the explanation this might be as a result of a degenerate life but seems not!

They are not sure what causes it but in the main, in my case, put it down to being the result of wear and tear damage – well I guess I’ve earned that diagnosis!

I gather that being more specific about diagnosis is not really worth the effort at this stage as the likelihood it will be some form of arthritic condition seems certain and clearly I am shrinking!

I have in fact lost about 3 inches in height largely as a result of the disease, though scoliosis and being cut in half do little to help!

SO BACK TO CANCER!:

It seems I have survived remarkably well to date! I am told that the Chemo. did indeed shrink the tumour and seems to have killed off the cancer in the lymph system – SEEMS is an important word here as it is, at this stage hard to tell!

Then having had, as described in this blog, very little side effects from the belting with chemo. it was on to Radio Therapy and 20 rides of around 57 seconds on the Linear Accelerator being cooked with accelerated electrons!

To date I have also survived this well – I was reliably informed that I would most likely be far too unwell to drive myself to treatment every day but fortunately I drove myself on every occasion and apart from around an hour in the evening when I felt very tired I have had virtually no side effects of consequence.

At the moment I am told there is little point in scans or a ‘flexi’ as the full effects have not completed adequately to conclusively show up and apparently the inside of the bladder is likely to be fragile and inflamed AND very prone to the introduction of infection so leave well alone.

Next appointment is now Mid October – which beats even the original 6 month prognosis at best!

SIDE EFFECTS:

It is not strictly true to say ZERO side effects but for sure they have so far been inconsequential.

At one stage for a day or two I had perifferal vision flashes which were a bit odd and I guess must have been an effect on the optic nerve of the blood supply due to cancer (maybe not!).

Fortunately I have not felt sick at any stage and my appetite has been fairly good – largely due to the efforts of Lee in pandering to it! Also to be fair thanks to Nairn in the early stages for the constant supply of relevant mouth washes such as ‘Difflam‘ which controlled the problems of mouth tongue and upper throat ulcers, which only really featured in the early days of Chemo.

There have been periods of mild diarrhea but of little consequence and with the hernia to my nephrectomy wound I have got used to this!

Several of the other patients have said their diarrhea has been quite a problem at times – fortunately mine has been only occasional and no problem.

There is no doubt they have been playing merry hell with my bladder! Particularly during Radio Therapy and I am urinating far too often for convenience! Particularly at night where I rarely get more than around 2.1/2 hours of continuous sleep without a visit to the toilet!

To be fair I do consume a fairly high level of fluid with around 2 pints of fruit juice a day minimum and at least 4 pints of milky strong coffee.

I also consume not less than a pint of yoghurt a day in one form or another – I FEEL that since the system is being bombarded and the gut flora seriously damaged or at best irritated it is worth helping with a replacement together with a consequential amount of fruit relative to normal.

Well if the treatment is working and these are the worst symptoms so far I would call this a very good trade off – though we will not know just how successful the treatment has been for a few months. That said the very fact that I am still here is very much down to the treatment as in April I well recal Jason Lester’s prognosis that without treatment I had a probable 3 months at best 6. Well I’m still here and feeling OK – of course not 100% energy wise but beyond that I can hardly complain and this is after all 13 years after I first presented with ‘frank haematuria’ (I miss spelled that and MS correction was ‘crematoria’ Ha Ha!) as the first symptoms of all the fun to come since!!

Haematuria:

A passing tip for those who are too scared to go to their Doctor if they think they may have blood in the urine the obvious diagnosis is ‘stupidity’!

Blood in the urine is a SYMPTOM only go see your Doctor as soon as possible – most causes can be dealt with simply the others WILL KILL YOU if you let them get hold undiagnosed!

A simple test if you are in doubt is to pass ALL urine into a glass (clean) coffee jar and leave it to stand until naturally cooled blood in the urine is likely to settle out as a distinct band but just because it doesn’t does NOT mean you should avoid seeing your Doctor.

Blood in the urine is also an early sign of possible diabetes and minded that The EU is threatening to withdraw driving licences from those with diabetes who let it reach the stage of injectable Insulin perhaps an early check is well advised!
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 Please Be Sure To
My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.
If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms see The TAB just below the Header of this Blog. called >DIARY of Cancer< just click and it will give you a long list of the main events in chronological order.
.
Thoughts and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Right Sidebar.

You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help.
.
YOU are welcome to call me if you believe I can help in ANY way.
.

Posted by: Greg Lance-Watkins
tel: 01291 – 62 65 62
on: http://GregLanceWatkins.Blogspot.com  
TWITTER: Greg_LW  
Health/Cancer Blog: http://GregLW.blogspot.com  
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22-Feb-2011 – Reducing drug side effects with nanoparticles

22-Feb-2011 – Reducing drug side effects with nanoparticles

Posted: Feb 22nd, 2011
Reducing drug side effects with nanoparticles

(Nanowerk News) Researchers at the Massachusetts Institute of Technology (MIT) and Brigham and Women’s Hospital have shown that they can deliver the cancer drug cisplatin much more effectively and safely in a form that has been encapsulated in a nanoparticle targeted to prostate tumor cells. Using the new particles, the researchers were able to successfully shrink tumors in mice, using only one-third the amount of conventional cisplatin needed to achieve the same effect. Such a dose reduction, should these results hold in human clinical trials, could help reduce cisplatin’s potentially severe side effects, which include kidney damage and nerve damage.

In 2008, this research team, headed by Stephen Lippard and Omid Farokhzad, a member of the MIT-Harvard Center of Cancer Nanotechnology Excellence (CCNE) funded by the National Cancer Institute, showed that the nanoparticles worked in cancer cells grown in a lab dish. Now that the particles have shown promise in animals, the team hopes to move on to human tests. “At each stage, it’s possible there will be new roadblocks that will come up, but you just keep trying,” says Dr. Lippard. The results of these investigations were published in the Proceedings of the National Academy of Sciences (“Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo”).

Cisplatin, which doctors began using to treat cancer in the late 1970s, destroys cancer cells by damaging their DNA, which ultimately triggers cell death. Despite its adverse side effects, which also include nausea, about half of all cancer patients receiving chemotherapy are taking platinum drugs. And in addition, cisplatin suffers from other problems that ultimately limit the utility of this potent tumor-killing agent. One problem with the drug is that conventional cisplatin remains in the bloodstream for only a short period of time. In fact, only about one percent of the dose given to a patient ever reaches the tumor cells’ DNA, with about half of any given dose being excreted from the body within an hour of treatment.

To prolong the time in circulation, Drs. Lippard and Farokhzad and their collaborators decided to encase a derivative of cisplatin in a hydrophobic (water-repelling) nanoparticle. First, the researchers modified the drug, which is normally hydrophilic (water-attracting), with two hexanoic acid units — organic fragments that repel water. That modification enabled them to encapsulate the resulting prodrug — a form that is inactive until it enters a target cell — in a nanoparticle.
Using this approach, far more of the drug reaches the tumor. The researchers found that the nanoparticles circulated in the bloodstream for about 24 hours, at least 5 times longer than un-encapsulated cisplatin. They also found that it did not accumulate as much in the kidneys as conventional cisplatin, which could reduce the dose-limiting kidney toxicity that limits the duration of cisplatin treatment today. To help the nanoparticles reach their target, the researchers also coated them with molecules that bind to prostate specific membrane antigen (PSMA), a protein found on most prostate cancer cells.

After showing that nanoparticles improved ciplatin’s lifetime in the blood stream, the researchers tested their effectiveness by treating mice implanted with human prostate tumors. They found that the nanoparticles reduced tumor size as much as conventional cisplatin over 30 days, but with only 30 percent of the dose normally required to see such a therapeutic response.

The particles tested in this paper are based on the same design as particles developed by Farokhzad and his MIT colleague Robert Langer, who is the co-principal investigator of the MIT-Harvard CCNE, to more effectively deliver the cancer drug docetaxel to tumors. A Phase I clinical trial to assess those particles, run by BIND Biosciences, commenced in January. Additional animal testing is needed before the cisplatin-carrying particles can go into human clinical trials, says Farokhzad. “At the end of the day, if the development results are all promising, then we would hope to put something like this in humans within the next three years,” he says.

To view the original article CLICK HERE

I just want to say sorry for copping out at times and leaving Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.
If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms see The TAB just below the Header of this Blog. called >DIARY of Cancer< just click and it will give you a long list of the main events in chronological order.
.
Thoughts and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Right Sidebar.

You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help. . YOU are welcome to call me if you believe I can help in ANY way.
.

Posted by: Greg Lance-Watkins
tel: 01291 – 62 65 62