17-Apr-2011 – Casual Reading AS YOU DO!! ‘CISPLATIN’
A recent article in the Mich. State University Alumni magazine (Spring 2011)
talks about the late Dr. Barney Rosenberg who developed the anti-cancer drug
Cisplatin (Platinol) and used with carboplatin (Paraplatin)- these two drugs are
rarely used alone.
” They are key ingredients in many combinations of drugs,
radiation and surgery that make cancers survivable, according to the director of
clinical research of one of the world’s top cancer hospitals.
Cisplatin became the backbone of combination therapy for testicular,bladder,lung,ovarian,head and
neck,gastric cancers and recently for triple negative breast cancer and a number
of other less common tumors”
according to Bruce A. Chabner in Rosenberg’s obituary published in Cancer Research.
The MSU article further states
“Caplatin and oxaliplatin(developed in Japan) have further extended this range of benefit.
The patients cured by these regiments and those that have benefitted from this
therapy number in the millions.” Tumors of the kidney are included in the list
of cancers I found out.
& In Reply:
Cisplatin has been around a long time (1970″s) as a cancer treatment.
It is VERY toxic to the kidneys, causes neuropathy and hasn’t shown a great response rate in general for RCC-like 17%. But is usedsucessfully for sarcomas so it is more likely to be used for kidney cancer with sarcomoid features. http://annonc.oxfordjournals.org/content/13/1/116.full.pdf
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