Life's Roller Coaster

If I'm missing, or not taking messages sorry – I'm more angry about letting my friends down than YOU will ever be at being let down! Unfortunately that is sometimes a side effect of Cancer! Mea Culpa: may I blame being short fused & grumpy on it too! My first symptoms presented in Nov-1998 – Follow The Trail on >DIARY of CANCER< Immediately Below!

Lung Cancer Mutations Maybe More Treatment Options

Lung Cancer Mutations Maybe More Treatment Options
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To Spread The Facts World Wide

To Give Hope & Information

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Discovery of New Lung Cancer Mutations May Mean More Treatment Options

DNA Sequencing

The identification of 4 new types of genetic mutations in the most common form of lung cancer could open the door for targeted treatment options for many more patients. This discovery adds to the existing scope of known lung cancer mutations.

When doctors know that a patient’s lung cancer has specific genetic mutations, they can selectively target it with certain drugs. If the cancer doesn’t have any of these mutations, the doctor is left with fewer treatment options.

Now, according to researchers, more than 75% of lung adenocarcinoma patients have been found to have genetic alterations that doctors might be able to use to help inform treatment decisions. Previously, that figure stood at 62%. There are more than 224,000 new cases of lung cancer each year in the U.S. and nearly 160,000 deaths from it, meaning this increase in known mutations has the potential to impact a large number of patients.

The 4 new mutations are detailed in a study published online July 9, 2014 in the journal Nature. The research team analyzed 230 lung adenocarcinoma tumor samples from The Cancer Genome Atlas (TCGA), a project of the National Institutes of Health.

“Two out of the 4 new mutations have been linked to lung cancer in some capacity previously and there are already some drugs out there for them – so there is some immediate potential for treatment,” says Alice Berger, Ph.D., a researcher at the Dana-Farber Cancer Institute and co-author on the study. Berger’s work on the investigation that led to the findings is funded in part by a $150,000 grant from the American Cancer Society. The other 2 newly discovered mutations present opportunities and impetus for the development of new drugs, according to Berger.

“If you don’t have an existing known mutation, once you stop responding to chemotherapy, then clinicians are in the dark about what else to try, but now, with knowledge of these other genetic alterations, it will give clinicians better options,” says Berger.

Spurred to Search for Remaining Mutations

For Berger, beyond the ability to now target the newly identified mutations, the findings showcase the value of continuing to look for specific genetic mutations that are causing lung cancer. “It continues to motivate us to do more sequencing to increase the power of our studies so we can identify rare mutations that may be very relevant for the remaining 24% [of lung adenocarcinoma patients] with tumors with still unknown mutations,” says Berger.

The study findings and the continuation of Berger’s work cataloging the genes that are most important in lung cancer will lead to doctors “being able to manage more patients in a personalized manner,” says William Phelps, Ph.D., director of preclinical and translational cancer research at the American Cancer Society.

Finding new genetic targets for lung cancer – or any cancer – is no small task, though. “There are really an astonishingly high number of mutations in every person’s tumor,” says Berger. “So, we have identified thousands and thousands, but the question is: how many are important and shared in tumors?”

Getting to an answer requires extensive sequencing of large numbers of tumor samples, something The Cancer Genome Atlas project is uniquely structured to do, adds Berger. And, it is not just about sequencing DNA anymore. Berger and her partners were also able to sequence the RNA of the tumor samples.

The ability to look at both DNA and RNA data is what “really enabled us to identify some of these newer alterations, because for some specific cases there are things that would have been hard to detect only in DNA,” says Berger. “We can now get a fuller picture of what is going on in these tumors.”

FOR RESEARCHERS: Learn how to apply for a research grant from the American Cancer Society.

Read more about American Cancer Society researchers.
 

To view the original of this article CLICK HERE

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Regards,
Greg_L-W.
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 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

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If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings.
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Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar.
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You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
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YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help in ANY way. .

Posted by: Greg Lance-Watkins

tel: 01594 – 528 337
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26-Apr-2011 – Nairn from St. DAVID’s – A First Foray

26-Apr-2011 – Nairn from St. DAVID’s – A First Foray

Europe - Mortality rate for men of lung cancer...Image via Wikipedia

Hi,

I tripped over the map of cancer morbidity from lung cancer for men in 2006 and thought it might interest.

Today Nairn from St.David’s phoned me and we had a chat – she has joined those reading my blog!

I’m fairly sure sure I know her but I can’t place her accurately, but she confirms we have met, and she also knows Lee from when Lee’s Mother Jean Rowland was suffering from terminal Brain Cancer – which was far too young and much too ugly!

Nairn is St. David’s nurse based in Chepstow and only too willing to help in any way she can.

We were discussing prognosis, treatment and side effects and when I explained my mouth ulcers and the fact that nothing seemed to make them much more bearable – even when I asked if mouth wash came in 50 gallon drums to save on packaging – I’m still using the two mentioned in an earlier blog but although they help it is none too wonderful – Nairn was really helpful.

She suggested a couple of products and then said since I had not tried them she would have a chat with one of the Doctors and get a prescription phoned through.

I’m really pleased that Wales has opted for free prescriptions – not that pay prescriptions were too scarey but just for mouth wash on Saturday I spent £20 and having drawn ZERO income since we shut the shop almost 7 years ago cash is at a premium! I have been loath to draw on Government and benefits as foolish as it may seem to some we can cope without State aid – it may be a struggle at times now that I have been off work with cancer for over 10 years!

It is a great relief that we bought our property and have thus kept our bills down and it was why it was so particularly vile of UKIP as a political party to abrogate on political argument and resort to dishonesty and lies to try to silence my opinions and the facts I publish on CLICK HERE the dishonesty in their inability to act with honour and integrity was beneath contempt and tells you all you need to know about UKIP and what a vile prospect they offer if ever elected.

If you want more details of their dishonourable and contemptible behaviour CLICK HERE these unpleasant cowards are only too happy to use any underhand method to silence the criticism of their supporters and there were even woops of glee published by at least one member of UKIP’s leadership team when my cancer was announced.

For more details CLICK HERE

There has been no apology nor censure from UKIP, The CIB or the debased Freedom Association (still trading on the reputation of its founder Norris McWhirter!) Yet the comments were clearly endorsed by these three organisations.

Fortunately such filth are in a minority in life – significant but a tiny and contemptible minority.

I was spared the exposition of another blue bell blown up ad absurdum to show a photographic fault had there been a possibility that the bell would have dwarfed those of Notre Dame and look what that did to Quasi Modo!

The phone rang and Nairn has sorted a prescription which will be with Boots in the morning and I can thus pick it up on route to Velindre for the next dosing of chemo.

As you can see from the >CANCER DIARY II< on the >TAB< at the top I have to be at Velindre by 11:00hrs. for a full set of bloods and as the lab insists on a full close for lunch from 12:00 to 14:00hrs. I shall then have to hang around until the results come through to the chemo cardboard box to start my infussion but as I recall tomorrows dose is a single chemical ‘gemcitabine’.

Tomorrow will tell! Though I do admit that having Nairn available to hand hold or to help Lee or I does make a difference – especially as much of the battle is to keep confident and have a positive attitude.

I just want to say sorry for copping out at times and leaving Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

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If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms see The TAB just below the Header of this Blog. called >DIARY of Cancer< just click and it will give you a long list of the main events in chronological order.
.
Thoughts and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Right Sidebar.

You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help.
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YOU are welcome to call me if you believe I can help in ANY way. .

Posted by: Greg Lance-Watkins
tel: 01291 – 62 65 62

25-Apr-2011 – Efforts To Prove My ID to be able to die!!! Even If I Don’t Want It For Years ;-)

25-Apr-2011 – Efforts To Prove My ID to be able to die!!!
Even If I Don’t Want It For Years 😉

Hi,

I probably only spent a total of 6 or 7 minutes in direct sunlight on Saturday in and out of a few shops and friends’ but I was aware of a sore (not very) scalp on this morning when I brushed my hair after a shower.

I shall have to be even more carefull of the side effect of sensitivity to the sun!

ME sensative to the sun!!!

Well off to Cribbs Causeway (shopping center at Junction 17 on the M5), Lee drove as she needs the practice in case I am unable to drive for her at some stage.

What a revolting concept shopping centers are, with their erzats blandness and impersonal sameness – it is extrodinary as one walks towards a shop assistant how, like some photo electric cell sensitive doll, they stand up straight gaining at least 2″ and develope plastic smiles to go with their part trained modulated offers of assistance!

We were able to get what I wanted but not a staff object in sight! I wanted some photos for a new passport – you would be astonished at how much ID is needed for legal forms and payments – Funny but no one has ever asked me for ID when they extort money FROM me.

Lee wanted a larger memory for her Olympus camera – probably to justify all the lenses!

She is struggling to come to terms with both the new technology AND the new camera which seems to do everything but make tea!!

Me technocrass so I avoid all settings on all cameras and try to work out what >AUTO< is but Lee feels a need to work out what all the buttons do and in howmany different ways!!!

I have a Canon IXUS130 which is small enough to carry in my waistcoat pocket and has a huge screen big enough for me to see. Yes I said see – there is no implication therein that I understand what I see!

Photography to me is strictly point and press despite having owned 10s of £1,000 of cameras over the years – I have NEVER had much interest in viewing the world through a view finder.

Whatever! Well we upgraded the memory so now I presume Lee will feel a need to upgrade her understanding of the complexity, which may explain why she is getting up early in the morning to act as a guid for Simon and a couple of friends who are near professional in their ability. Off to a few of the very impressive bluebell woods and view points around Speech House in The Forest of Dean.

On the way home we dropped in to see Gerald & Carol as being a Financial Adviser he is kindly sorting out various details for me – whether it is the illness, the treatment or just that I have an excuse now I just so hate ‘Bumf’. I lose patience witjh it in a matter of minutes.

Eventually we left at about 21:00hrs. as I was starting to flag a little, I lack energy which strangely comes in waves!

My mouth and swallowing are both very sore with ulcers as a side effect of chemo and the mouth washes etc. are doing little to control the discomfort nor the feeling my tongue has doubled in width and is raw – which produces extra saliva which means yet more painful swallowing!

Yes I’m being self indulgent and complaining but I have been immensly lucky as apart from a rather jaded feeling and a sore mouth I seem so far to have avoided the expected side effects and the pag of various anti sickness pills remains unopened!

Do remember this blogs aim is to tell the story warts and all to help others facing down the Grim Reaper with a deck stacked against them. Whatever the bastard’s disguise:

I have age and general fitness on my side and also 13 years of practice so lets see if we can beat the bastard for another 13 years!

Alan, my Father’s youngest brother is now 83 and as a result of losing his voice a couple of months ago has recently been diagnosed with cancer on the lung which is putting pressure on the nerve controlling the vocal chords.

As yet they have no firm treatment plan for him but let us hope it is a slow acting version at his age as with Simon (his son) living in West Virgina and now an American citizen to loose his voice and not be able to speak with him would be an added irritant. Simon’s wife Paula’s parents live locally to Alan & Brenda but although younger her Father is having his own second battle with The Reaper – so that is the three of us with cancer – woopy doo!

I just want to say sorry for copping out at times and leaving Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.
If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms see The TAB just below the Header of this Blog. called >DIARY of Cancer< just click and it will give you a long list of the main events in chronological order.
.
Thoughts and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Right Sidebar. You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help.
.
YOU are welcome to call me if you believe I can help in ANY way.
.

Posted by: Greg Lance-Watkins
tel: 01291 – 62 65 62