Partial Nephrectomy Prolongs Survival in Younger Patients

The 10-year overall survival rate was 94% for partial nephrectomy compared with 89.7% for radical nephrectomy in patients aged 20-44.

Survival Rates Unchanged for Patients with Advanced RCC

Relative survival rates for patients with advanced renal cell carcinoma have not improved significantly in the era of targeted agents.

Drugs for Metastatic Kidney Cancer Offer Similar Survival

Final overall survival data from a phase 3 trial reveal no significant difference between tivozanib and sorafenib.

The Role of Renal Tumor Biopsy

With a growing number of small renal masses being detected, renal tumor biopsies should be performed more frequently.

New Targets for Preventing Kidney Cancer Metastasis

A team of investigators suggests the use of two new specific targets for preventing metastasis in patients with clear cell renal cell carcinoma.

Biopsy-Based Algorithm Found Accurate for Small Renal Masses

Compared with final pathology, biopsies can accurately inform treatment algorithm

One Hospital Night OK for Robotic Partial Nephrectomy

Readmission rate of 2.7% with discharge on postoperative day one

Small Renal Cancers Can Recur Even 10 Years Post-Op

Microvascular invasion identified as risk factor for cancer-specific death.

Kidney Tumor Ablation Ideal for Selected Patients

British radiologist/researcher discusses her experience with cryotherapy and radiofrequency ablation.

Kidney Cancer Biomarkers Remain Elusive

The clinical trials needed to identify biomarkers are complex and difficult, British researcher says.

Higher Post-Nephrectomy Transfusion Rate Found

Large study reveals an 18.1% prevalence overall, with the prevalence ranging from 8.6% to 28.2% depending on the surgical approach.

Pre-treatment Percutaneous 
Biopsy of Small Renal Masses

Urologists typically treat a renal cortical mass without biopsy, but this should be re-evaluated in the era of the incidental small renal cortical neoplasm.

Microscopic Hematuria Rarely Indicates Urinary Tract Cancer

Many patients may be able to avoid extensive follow-up examinations.

Partial Nephrectomy PSMs Do Not Raise Death Risk

Five-year overall and cancer-specific survival similar for patients with and without positive surgical margins.

Preoperative ESR Predicts Kidney Cancer Survival After Nephrectomy

Preoperative anemia associated with elevated risk of deaths from other illnesses.

US-Guided Core Biopsy Feasible, Safe for Small Renal Masses

Study also reveals factors associated with non-diagnostic specimens.

The Association Between Kidney Failure and Renal Cell Carcinoma

Scientific speculation suggests that uremic toxins, viral mediators, and immune ­inhibition could play a role in malignant transformation.

Partial Nephrectomy Offers Better Renal Preservation, Survival

This surgical approach is associated with a lower risk of developing stage IV CKD compared with radical nephrectomy.

R.E.N.A.L. Nephrometry Score Predicts Treatment Efficacy

Predicts oncological outcomes and major complications after percutaneous renal ablation

Data Support Active Surveillance for Small Renal Masses

Active surveillance of small kidney masses is a safe and effective alternative to immediate surgery, with similar overall and cancer-specific survival rates.

RAPN Found Safe for Larger Renal Tumors

RAPN is a possible alternative to open nephrectomy for treating patients with renal tumors larger than 4 cm, researchers say.

Overweight Teens at Higher Risk for ESRD

End-stage renal disease is three times and nearly seven times more likely to occur in overweight and obese adolescents, respectively.

PCA for Renal Tumors Safe, Effective for High-Risk Patients

Percutaneous cryoablation is associated with an 87% treatment success rate and 9% complication rate in elderly patients with significant comorbidities.

Bisphosphonates Added to RCC Therapy May Improve Outcomes

Concomitant use of oral TKIs with bisphosphonates appear to be associated with improved outcomes in patients with RCC and bone involvement.

Survival Advantage for Whites With Renal Cell Carcinoma

Although more blacks diagnosed with localized stage, smaller tumors, less aggressive subtype

Stereotactic Radiosurgery Promising for Renal Cancer

The modality may provide a safe noninvasive treatment option.

Robotic Partial Nephrectomy Advance Reported

A new type of robotic-assisted surgery is streamlining partial nephrectomy.

Study: Percutaneous Renal Biopsies Safe

Researchers in Norway demonstrate a less than 1% overall rate of complications.

Axitinib, Sorafenib Offer Similar Survival in mRCC Patients

Updated findings show overall survival in patients receiving the drugs as second-line treatment.

Data Back New Drug for First-Line mRCC Therapy

Pazopanib and sunitinib demonstrated similar progression-free and overall survival.

Possible New Predictor of RCC Response to mTor Treatment

A new study suggests that high levels of lactate dehydrogenase may predict how renal cell carcinoma will respond to an mTor (mammalian target of rapamycin) inhibitor.

Peripheral Renal Tumors More Likely to Be Benign

Tumor location and body mass index (BMI) may be useful for identifying which renal tumors are likely to be benign prior to surgery.

Partial Nephrectomy Cuts ED Risk

A retrospective study has found that men who undergo total nephrectomy for renal cell carcinoma may be 3.5 times more likely to develop erectile dysfunction.

Kidney Cancer Vaccine May Extend Lives

German researchers report that the kidney cancer vaccine IMA901 may prolong patient survival.

Robotic NSS Without Ischemia for Exophytic Small Renal Masses

As nephron-sparing surgery has become widely accepted, increasing emphasis has been placed on reducing surgical morbidity.

Biomarker Found to Predict Therapy Benefit in Renal Cancer

Lactate dehydrogenase significant prognostic biomarker in poor-risk renal cell carcinoma

Hyponatremia May Shorten RCC Survival

Hyponatremia is associated with shorter cancer-specific survival in patients with metastatic renal cell carcinoma treated with molecular targeted therapy.

Laparoscopic Cryoablation Offers Excellent Long-Term Outcomes

Patients who underwent the procedure experienced no significant change in renal function.

RCC or Dialysis: Risk Stratification and Assessment

Risk-stratifying patients requires a urologist’s understanding of the natural history of disease, competing risks, and morbidities of interventions.

Larger Kidneys Increase RCC Death Risk

Each 1-cm increment in kidney size was associated with an 18% increased risk of death from renal cell carcinoma.

‘Firefly’ May Aid Kidney Cancer Surgery

A surgical technology called Firefly is shedding new light on renal cell carcinoma and helping physicians in a new way.

Native Kidney RCC Outcomes Vary by ESRD Treatment

Renal transplant recipients have better cancer-specific survival than dialysis patients.

Lower ED Risk with Partial Nephrectomy

Erectile dysfunction (ED) is less likely to develop postoperatively in men who undergo partial rather than radical nephrectomy, a study found.

CRP May Predict Sunitinib Response

C-reactive protein (CRP) is a significant prognostic indicator in patients with advanced renal cell carcinoma (RCC) treated with sunitinib.

Similar Outcomes for Robot-Aided, Conventional Nephrectomy

Post-op complication rates, distributions similar for laparoscopic partial nephrectomy techniques

Post-Nephrectomy Transfusion Rate is Underestimated

The rate of perioperative blood transfusion after nephrectomy appears to be higher in general practice than the rates commonly cited in published urologic reports.

RCC Death Risk Greater with Ablation than Nephron-Sparing Surgery

The risk of death is twofold higher, but the difference in absolute risk at five years is small, researchers say.

Axitinib May Be Effective as First-Line Therapy for mRCC

CHICAGO—Axitinib appears to be effective in the first-line treatment of metastatic renal cell carcinoma as evidenced by a long progression-free survival and a high objective response rate.

Little Cardiac Toxicity with Sunitinib, Sorafenib

CHICAGO—Sunitinib and sorafenib for adjuvant therapy will likely not cause significant cardiac toxicity in patients with resected renal cell carcinoma.

Axitinib May Offer Advantage Over Sorafenib for mRCC

CHICAGO—Axitinib may provide better outcomes than sorafenib as second-line treatment for patients with metastatic renal cell carcinoma (mRCC) previously treated with cytokines, according to a new study.

Partial Nephrectomy Preferred for Some Patients

A new study by researchers at the University of Michigan suggests that partial nephrectomy should be the preferred treatment for patients who are candidates for it.

Patient RCC Drug Preferences Revealed

CHICAGO—Patients with metastatic renal cell carcinoma prefer pazopanib over sunitinib because the former is associated with a better quality of life and less fatigue.

Vasculitis Patients Have Poor Grasp of Treatment Effects

PARIS—Patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis have substantial knowledge deficits about potential treatment-related adverse effects, according to data from a British survey.

Partial Nephrectomy Is An Option for Larger Tumors

Partial nephrectomy (PN) can be safely performed in patients with renal tumors 7 cm or more in diameter with acceptable technical, oncologic and functional outcomes, according to researchers.

Aspirin Found to Protect Against Kidney Cancer

New data on cancer metastases and mortality rates suggest that daily aspirin in older adults may help combat renal cell carcinoma (RCC).

Renal, Urothelial Cancers Linked to Lower Kidney Function

Lower renal function is associated with an increased independent risk for renal and urothelial cancer, according to data presented at the American Urological Association 2012 annual meeting.

Data Suggest Caution in the Use of Nonsurgical Management of Renal Tumors

New findings suggest a need to proceed with caution when deciding whether to use nonsurgical management (NSM) for patients with renal cell carcinoma, according to a report presented at the American Urological Association 2012 annual meeting.

Findings May Improve Mortality Predictions for RCC Patients

New findings may better enable clinicians to predict cancer-specific and other-cause mortality among patients who have undergone nephrectomy for renal cell carcinoma (RCC), according to a report presented at the American Urological Association 2012 annual meeting.

Preoperative Imaging May Avert Unnecessary Adrenalectomy

Preoperative cross-sectional imaging can prevent unnecessary adrenalectomy in patients undergoing radical nephrectomy for renal cell carcinoma (RCC), according to findings presented at the American Urological Association 2012 annual meeting.

Study Identifies RCC Risk Factors

A history of kidney disease, hypertension, high body mass index (BMI), and smoking are independently associated with an increased risk of renal cell carcinoma (RCC), researchers reported at the American Urological Association 2012 annual meeting.

Survival Better with Partial Nephrectomy

Partial nephrectomy (PN) is associated with better overall survival compared with radical nephrectomy (RN) for patients with early-stage kidney cancer, researchers reported at the American Urological Association 2012 annual meeting.

RCC Subtype Is Associated With Low Recurrence Rate

Patients with papillary renal cell carcinoma (pRCC) have a low risk of tumor recurrence and cancer-related death after surgery.

Drug Cleared for Treating Renal Angiomyolipomas

The FDA has approved everolimus (Afinitor) for the treatment of renal angiomyolipomas and tuberous sclerosis complex (TSC) in adult kidney tumor patients who do not require immediate surgery.

Active Surveillance May Be Okay for Some Men with Metastatic Kidney Cancer

Active surveillance may be appropriate for up to 10% of patients with metastatic kidney cancer, according to researchers at the Cleveland Clinic.

Sickle Cell Trait and Medullary Renal Carcinoma

Since the discovery of Hemoglobin S (HbS), it has been known that the abnormal polymerization of deoxy-HbS is the main cause for vaso-occlusive crisis involving many organs including the kidneys in sickle cell disease (SCD).

Preventing Needless Nephrectomies Possible

SAN FRANCISCO—Percutaneous image-guided renal mass biopsy (RMB) combined with immunohistochemical (IHC) results can accurately distinguish between benign and malignant tumors, a finding that could help prevent unnecessary nephrectomies, researchers reported at the 37th Annual Scientific Meeting of the Society of Interventional Radiology.

Targeted Therapies Have Improved Survival Among Patients with Metastatic RCC

Overall survival appears to be improving significantly in patients with metastatic renal cell carcinoma (RCC).

Image-Guided Ablation a Viable Treatment for Small Renal Tumors

SAN FRANCISCO—Image-guided ablation of primary renal cancers smaller than 4.8 cm may be performed with minimal morbidity and produce excellent results in terms of long-term survival, according to a new study presented at the 37th Annual Scientific Meeting of the Society of Interventional Radiology.

RFA Successfully Treats Small Benign Renal Tumors

Radiofrequency ablation (RFA) can effectively treat small benign tumors in a single session, and long-term outcomes of RFA for renal tumors depend on tumor size, according to the findings of two studies.

Hemodialysis Patients Not More Likely to Die from Renal Cell Carcinoma

PARIS—Hemodialysis (HD) patients are no more likely to die from renal cell carcinoma (RCC) than patients with normal renal function, but they have decreased overall survival, Japanese investigators reported at the 27th Annual Congress of the European Association of Urology.

Study: Partial Nephrectomy Complications Mostly Minor

PARIS—Nearly one quarter of patients undergoing partial nephrectomy (PN) experience complications, but most are minor, a researcher reported at the 27th Annual Congress of the European Association of Urology.

Partial Nephrectomy Rates Rise, but Disparities Exist

PARIS—Partial nephrectomy (PN) rates have increased dramatically, but this surgical approach is underused in certain patient populations, according to data presented at the 27th Annual Congress of the European Association of Urology.

Renal Dysfunction After Radical Nephrectomy Raises Cardiovascular Risks

PARIS—Renal dysfunction following radical nephrectomy (RN) for renal cancer is associated with an increased risk of cardiovascular (CV) events and non-cancer-related mortality, Japanese researchers reported at the 27th Annual Congress of the European Association of Urology.

More Tailored Treatments for Kidney Cancer Possible

Two newly published studies provide a unique foundation for a more complete understanding of distinct kidney cancer subtypes.

Cryotherapy Can Successfully Treat Small Renal Masses

LONDON—Cryotherapy can be used to treat small renal tumors or masses successfully with relatively low rates of complications and recurrence, a urologist skilled in the technique told attendees at the Renal and Bladder Cancer 3rd National conference here.

Immunotherapy May Improve mRCC Outcomes

SAN FRANCISCO—An immunotherapy (AGS-003) in combination with sunitinib may help prolong the lives of men with unfavorable risk, metastatic renal cell carcinoma (mRCC), according to new data from an open-label phase 2 study.

Bisphosphonates May Improve Outcomes in Patients with RCC and Bone Metastases

SAN FRANCISCO—Combining a bisphosphonate with sunitinib may improve progression-free survival (PFS) and overall survival (OS) in patients with bone metastases from renal cell carcinoma (RCC), that are treated with sunitinib, according to a multicenter, retrospective study presented at the 2012 Genitourinary Cancer Symposium.

Prior Sunitinib Duration Affects Second-Line RCC Therapy Outcomes

SAN FRANCISCO—Prior sunitinib treatment for nine months or longer may be associated with a longer progression-free survival (PFS) in patients with metastatic renal cell carcinoma (RCC) receiving axitinib as second-line treatment, according to a new study presented at the 2012 Genitourinary Cancer Symposium.

Kidney Cancer Tumor Size, Preoperative eGFR Linked

Tumor diameter and decreased preoperative estimated glomerular filtration rate (eGFR) are independently correlated in patients undergoing surgery for renal cell carcinoma (RCC), researchers concluded.

Adrenalectomy Rates Remain High in Radical Nephrectomy

During a recent 10-year period, the rate of ipsilateral adrenalectomy at the time of radical nephrectomy decreased slightly, a study found.

Kidney Cancer Tied to Red Meat Intake

Greater intake of red meat may increase the risk of renal cell carcinoma (RCC).

Radiofrequency Ablation, Partial Nephrectomy for RCC Offer Similar Long-Term Outcomes

In appropriately selected patients, radiofrequency ablation (RFA) is an effective minimally invasive treatment for cT1a renal cell carcinoma (RCC) that offers long-term oncologic outcomes comparable to nephron-sparing surgery, data show.

Ultrasound Not Inferior for Sizing Renal Masses

Ultrasound imaging works as well as computed tomography (CT) and magnetic resonance imaging (MRI) for evaluating renal mass size, a new study suggests.

Increased Lead Exposure May Raise Kidney Cancer Risk

Higher blood lead levels are associated with an elevated risk of renal cell carcinoma (RCC), according to a study.

An Update on Robotic-Assisted Partial Nephrectomy

Short-term outcomes from early institutional experiences have confirmed the safety and feasibility of RPN, even for anatomically complex tumors.

Positive Surgical Margins Rare After Partial Nephrectomy

Positive surgical margins (PSMs) are rare in patients undergoing partial nephrectomy (PN) for kidney cancer, researchers found.

Panel Backs Axitinib for Advanced Kidney Cancer

The FDA’s Oncologic Drugs Advisory Committee, in a unanimous vote, agreed that data for the investigational drug axitinib (Pfizer) support a favorable benefit/risk profile for treating patients with advanced renal cell carcinoma (RCC) following failure of first-line systemic therapy.

Non-Cancer Death Less Likely with Partial Nephrectomy

Patients who undergo partial nephrectomy (PN) for localized renal cell carcinoma (RCC) are more likely to die from causes other than their cancer compared with patients treated with radical nephrectomy (RN), data show.

Survival Better with Incidentally Detected RCC

Incidental detection of renal cell carcinoma (RCC) is increasing and is associated with better survival from the malignancy, according to a population-based study conducted in Iceland.

Cancer Risk Higher in Transplant Recipients

Infection-related and unrelated cancers develop more frequently in solid organ transplant recipients than in the general population, according to researchers.

Study: Bone Risks Lower with NSS

Osteoporosis and fractures are significantly more likely to occur in patients undergoing radical nephrectomy (RN) than nephron-sparing surgery (NSS), researchers concluded.

Sunitinib’s Safety, Efficacy Confirmed

Expanded access trial shows poorer-risk patients can benefit from the drug for advanced kidney cancer.

Renal Function Preservation for Patients with Kidney Cancer

The renal function preservation clinic for patients with kidney cancer represents a new multidisciplinary approach to an old problem.

SBRT Offers More Durable Pain Relief in Advanced RCC Patients

MIAMI BEACH, Fla.—Conventional radiotherapy (CRT) and stereotactic body radiotherapy (SBRT) provide relief of pain related to spine metastases in patients with advanced renal cell carcinoma (RCC), but CRT provides more rapid relief and SBRT has a more durable effect, according to new data presented at the American Society for Radiation Oncology annual meeting.

Ultrasound Technique May Improve Renal Tumor Management

Novel noninvasive approach to evaluating tumor histology could identify patients who can avoid surgery

Study Links Renal Cancer, Multiple Myeloma

Researchers have identified a bidirectional association between renal cell carcinoma (RCC) and multiple myeloma, which suggests that common risk factors influence development of both malignancies, according to a recent report in BJU International.

Kidney Cancer Linked to Nonaspirin NSAIDs

Regular use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) may increase a person’s risk of renal cell cancer (RCC), new findings suggest.

Renal Laparoscopic Cryoablation Has Little Effect on Kidney Function

Patients undergoing laparoscopic cryoablation (LCA) for renal masses experience a minimal decline in renal function at mid-term follow-up, and this decline is similar for patients with and without chronic renal insufficiency (CRI), researchers concluded.

Early RCC Tumor Response to Sunitinib Bodes Well

Early reduction in primary tumor (PT) size independently predicts better overall survival in patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib, researchers reported.

Kidney Cancer vs. ESRD

Incidentally detected renal tumors are increasingly diagnosed in patients with chronic kidney disease.

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