Life's Roller Coaster

If I'm missing, or not taking messages sorry – I'm more angry about letting my friends down than YOU will ever be at being let down! Unfortunately that is sometimes a side effect of Cancer! Mea Culpa: may I blame being short fused & grumpy on it too! My first symptoms presented in Nov-1998 – Follow The Trail on >DIARY of CANCER< Immediately Below!

If I Had My Druthers I’druther Not Have Pancreatic Cancer & Why …

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If I Had My Druthers I’druther Not Have Pancreatic Cancer & Why …
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Posted by:
Greg Lance – Watkins
Greg_L-W

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Hi,

to put the facts below in some perspective: If you are 70 you have a meagre 7% chance of reaching 80, or to look at it another way – 93% of 70 year olds will die before they are 80.

It is a little like statistical prognosis in medicine, I well remember asking my consultant Windsor Bowsher, immediately prior to having my cancerous kidney removed what my prognosis was back in 2001, I well recall his response:

“I find that with this operation is done minded that it is by any description  very major surgery, those who don’t make it had a very poor prognosis and those that were a success had a good prognosis and I have no idea before the event which group you will be because you are an individual”

Why pancreatic cancer is so deadly

Story highlights

  • About 95 percent of people with pancreatic cancer die from it, experts say

  • As people age, the risk of developing pancreatic cancer goes up

  • There are two types of pancreatic cancer: exocrine tumors and endocrine tumors

This story was previously published in 2011, but has been updated with new statistics.

 

(CNN)Pancreatic cancer is the third-leading cause of death from cancer in the United States, after lung and colorectal cancers

 

The lifetime risk of developing it is about 1 in 63 for men, and 1 in 65 for women. This year, about 55,440 people will be diagnosed with pancreatic cancer, and the disease will kill about 44,330 people, according to the American Cancer Society.
About 95 percent of people with pancreatic cancer die from it, experts say. It’s so lethal because during the early stages, when the tumor would be most treatable, there are usually no symptoms. It tends to be discovered at advanced stages when abdominal pain or jaundice may result. Presently, there are no general screening tools.
As people age, the risk of developing pancreatic cancer goes up. Most patients are older than 45, and nearly 90% are older than 55. The average age at diagnosis is 71.
Men have a slightly higher likelihood of developing pancreatic cancer than women, which may partly result from increased tobacco use in men. In the past, when men more commonly smoked than women, the gender gap was wider.
There is also a noted association with race: African-Americans are more likely to develop pancreatic cancer than whites. Doctors don’t know why, but speculate that higher rates of men smoking and having diabetes, and women being overweight, may contribute to that association.

What are the types of pancreatic cancer?

The pancreas is an oblong organ that lies deep in the abdomen, and is an integral part of both the digestive and endocrine system. It secretes hormones to regulate the body and also digestive enzymes to break down food.
There are two types of pancreatic cancer: exocrine tumors and endocrine tumors.
Exocrine tumors are the majority of pancreatic cancers, and the most common form is called adenocarcinoma, which begin in gland cells, usually in the ducts of the pancreas. These tumors tend to be more aggressive than neuroendocrine tumors, the kind that Apple, Inc., co-founder Steve Jobs had, but if caught early enough they can be treated effectively with surgery.
Pancreatic neuroendocrine tumors constitute only 1% of all pancreatic cancers.
They can be benign or malignant, but the distinction is often unclear and sometimes apparent only when the cancer has spread beyond the pancreas.
The five-year survival rate for neuroendocrine tumors can range from 50% to 80%, compared with less than 5% for adenocarcinoma.
More advanced tumors have a higher risk of recurrence, and can spread to the liver, said Dr. Steven Libutti, pancreatic cancer expert and director of the Montefiore-Einstein Center for Cancer Care in the Bronx.

Treatment options

 

Pancreatic cancer is usually controllable only through removal by surgery, and only if found before it has spread, according to the National Cancer Institute. Palliative care can help a patient’s quality of life if the disease has spread.
Two drugs approved in 2011 may help patients with pancreatic neuroendocrine tumors. They are believed to suppress the blood supply and metabolism of the tumor cells. That’s good progress since, the year before, the standard of care was chemotherapy, said Dr. Michaela Banck, medical oncologist at the Mayo Clinic, who treats patients with neuroendocrine tumors.
Everolimus, marketed by Novartis as Afinitor, received U.S. Food and Drug Administration approval to treat pancreatic neuroendocrine tumors and prevents transplant rejection. Potential side effects are serious, however: lung or breathing problems, infections and renal failure, which may lead to death.
Sunitinib malate, marketed by Pfizer as Sutent, is prescribed for the treatment of pancreatic neuroendocrine tumors, as well as, kidney cancer and GIST, a rare cancer of the bowel, esophagus or stomach. As with everolimus, there are risks to consider: it can cause liver problems and death.
Jobs underwent surgery to remove his tumor in 2004 and died in 2011. His seven-year survival after treatment is consistent with the average survival for these kinds of tumors, Libutti said.
If pancreatic cancers are detected early, that may increase the odds of survival, but it also depends on how aggressive the particular tumors are in a patient. If surgery leaves behind microscopic aggressive tumor cells, they can cause a recurrence of cancer.
Jobs also underwent a liver transplant in Tennessee in 2009, which is “cutting edge stuff” for when neuroendocrine tumors spread, said Dr. Maged Rizk, director of the Chronic Abdominal Pain Center at the Cleveland Clinic who specializes in gastroenterology and hepatology.

Do transplants help?

Because it’s so rare, there isn’t a lot of evidence to support the transplant as a cure; the procedure could extend life, but immunosuppression drugs may allow any remaining cancer to grow faster, doctors say. And a European study found that the majority of patients who underwent liver transplant for this type of tumor had recurrence of the disease.
But many pancreatic cancers are detected in later stages because when the tumor is small, it often does not produce symptoms. As they grow, adenocarcinomas can obstruct the ducts from the liver and cause severe back pain. Neuroendocrine tumors sometimes produce insulin, so a patient’s first symptoms could be low glucose levels. But most tumors do not produce hormones, Libutti said.
There are two rare genetic syndromes — multiple endocrine neoplasia type 1 (MEN1) and Von Hippel-Lindau syndrome (VHL) — that increase the risk of pancreatic neuroendocrine tumors. Other than that, though, it’s unclear whether having a family member with pancreatic cancer increases an individual’s risk.
Pancreatic cancer struck former President Jimmy Carter’s family hard. He lost his father and all of his siblings, brother Billy and sisters Ruth Carter Stapleton and Gloria Carter Spann.

The future of treatment

Researchers are working on better understanding the way in which pancreatic tumors grow and spread, Libutti said. There is also a lot of research focused on finding better treatments, targeted therapies, immune therapy, improving surgery and radiation therapy, according to the American Cancer Society.
“There are a number of agents that are being looked at in clinical trials that focus on pathways that may allow pancreatic cancer to evade normal processes,” Libutti said.
Another line of research is focused on finding biomarkers of pancreatic cancer so that a simple blood or urine test could be developed. Unlike screenings for other conditions such as colon, breast and prostate cancers, there is no routine way to see whether a patient has a tumor in the pancreas.
The future of medicine to help people with pancreatic cancer will involve genetics, said Banck. This would involve matching a person’s particular type of tumor using genomic information with treatment.
“What’s going to make real difference in the future is the revolution of the genomic era,” she said.

To view the original article CLICK HERE

.
Regards,
     Greg_L-W
Greg Lance-Watkins
.
 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving my wife Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.

If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings. . Later in the sequence of my experiences with cancer you will note that I introduce some results and events most probably linked with cancer such as enlarged & damaged Prostate and a consequential Heart Attack leaving me with no right coronary artery! . I have also included numerous articles and anecdotes regarding health – primarily related to cancer, prostate and heart conditions – FYI! . Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar. . You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
.
YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help you in ANY way. .

Regards,
Greg_L-W.

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Posted by: Greg Lance-Watkins
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A Kidney Condition Puts Melania Trump in the Hospital …

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A Kidney Condition Puts Melania Trump in the Hospital …
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Posted by:
Greg Lance – Watkins
Greg_L-W

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Hi,

firstly lets wish Melania Trump a speedy and full recovery, with no future kidney or related scares, a fervent wish I make for all who have such issues.

Kidney Condition Puts Melania Trump in the Hospital

Image
Melania Trump, the first lady, underwent a surgical procedure on Monday morning. CreditDoug Mills/The New York Times

 

WASHINGTON — Melania Trump underwent a medical procedure on Monday morning to treat what the White House called a “benign kidney condition” and was reported to be recovering without trouble at a military hospital outside the capital.

“The procedure was successful and there were no complications,” the White House said in a statement. “Mrs. Trump is at Walter Reed National Military Medical Center and will likely remain there for the duration of the week. The first lady looks forward to a full recovery so she can continue her work on behalf of children everywhere.”

President Trump spoke with Mrs. Trump on Monday morning before the procedure and later spoke with the doctor after it was over, according to a White House official who asked not to be identified describing the private communications. In the late afternoon, the president flew by helicopter to Walter Reed to visit the first lady for about an hour before returning to the White House.“Heading over to Walter Reed Medical Center to see our great First Lady, Melania,” Mr. Trump said on Twitter. “Successful procedure, she is in good spirits. Thank you to all of the well-wishers!”

The White House said Mrs. Trump, 48, underwent an embolization procedure. The Johns Hopkins Patients’ Guide to Kidney Cancer describes an arterial embolization as a procedure in which a special spongelike material is placed into an artery that supplies blood to the kidney. A thin tube catheter is inserted into a vessel in the leg and into the main vessel feeding the kidney.

Such a procedure would block the blood supply that feeds the kidney and might be used to stop bleeding from a benign tumor, a small aneurysm or to reverse the growth of such a tumor, according to specialists. The Johns Hopkins guide said it can also be used to make it easier for a surgeon to remove the kidney but is more frequently used to control symptoms for someone who cannot undergo surgery.

 

Vice President Mike Pence said on Monday that Mrs. Trump’s procedure was “long-planned,” citing her visit to Walter Reed as the reason Mr. Trump had sent him to represent the administration at a reception hosted by the Israeli Embassy to celebrate the 70th anniversary of Israeli independence.

The fact that Mrs. Trump will remain in the hospital for the rest of the week was unusual in the most typical cases, according to leading medical experts.

“It’s like literally an outpatient procedure,” said Dr. Eleanor D. Lederer, a professor at the University of Louisville School of Medicine and past president of the American Society of Nephrology. “You go in, you have it done, you lie in bed for a while to keep the blood vessel from bleeding and then you go home.”

Another doctor, however, said Mrs. Trump was probably being kept in the hospital longer because of her position. “That’s because she is the first lady,” said Dr. Jeffrey Cadeddu, a professor of urology and radiology at the University of Texas Southwestern Medical Center in Dallas. “If it was you, you’d be in and out in a day, I promise.”

Still, embolization kills some surrounding healthy kidney tissue, which causes swelling and pain as a patient recovers, so a longer stay could be helpful or necessary, doctors said.

The White House did not explain what led Mrs. Trump to seek treatment or whether the “benign kidney condition” meant she had a benign tumor or something else. Specialists said it could be that doctors had been monitoring a mass for a while and decided to act on it now because it had grown. Or they said it could be that she experienced symptoms of some sort, like noticing blood in the urine or experiencing back pain or stomach pain.

Doctors may also have discovered bleeding while conducting routine tests for other reasons.

Dr. Joseph A. Vassalotti, the chief medical officer at the National Kidney Foundation, said his guess was that Mrs. Trump had either a benign tumor known as an angiomyolipoma or a bleeding cyst. “It sounds like it was a benign tumor,” he said.

Dr. David G. Warnock, an emeritus professor of medicine at the University of Alabama at Birmingham and a past president of the kidney foundation, said doctors frequently perform an embolization if a biopsy or other diagnostic procedure causes bleeding.

“My list of benign conditions that you’d embolize is pretty short,” he said. “Ninety percent of them are to stop bleeding after some procedure like a kidney biopsy.”

But Dr. Joseph V. Bonventre, chief of the renal unit at Brigham and Women’s Hospital in Boston said that it was unlikely Mrs. Trump would have a biopsy on this type of tumor and that doctors probably decided to conduct the embolization procedure to prevent a benign tumor from growing by starving it of blood, and therefore oxygen.

“In general, you want to embolize it because you don’t want it to continue to get bigger and erode into the larger vessels of the kidney where it can cause significant bleeding,” he said. He added that embolizing in this case was “most likely a preventive thing.”

The procedure came just a week after Mrs. Trump formally kicked off a public campaign to encourage children to put kindness first in their lives, particularly on social media. She has generally maintained a low profile during her 16 months as first lady, focusing primarily on raising her son, Barron.

Mrs. Trump makes a point of leading a healthy lifestyle. In New York, she has said she would walk with ankle weights and eat seven pieces of fruit every day. “I live a healthy life, I take care of my skin and my body,” she told GQ in 2016. “I’m against Botox, I’m against injections; I think it’s damaging your face, damaging your nerves. It’s all me. I will age gracefully, as my mom does.”

The health of first ladies has long been a factor in White House life. Three first ladies died while living in the White House — Letitia Tyler (wife of John Tyler), Caroline Harrison (wife of Benjamin Harrison) and Ellen Wilson (wife of Woodrow Wilson) — and Andrew Jackson’s wife, Rachel, died between his election and inauguration.

Others have suffered serious ailments that, for much of the country’s history, were shrouded from the public. In recent decades, first ladies have been more open, although not in every instance. Betty Ford set the tone for modern times by being open about having a mastectomy to fight breast cancer. Following her example, Nancy Reagan also disclosed her own mastectomy, although she limited the details released.

Barbara Bush disclosed her Graves’ disease, a thyroid condition, while living in the White House. Her daughter-in-law, Laura Bush, however did not reveal that she had a skin cancer tumor removed from her shin until weeks later, deeming it “no big deal at the time.”

To view the original article CLICK HERE

Do note that a friend of mine who is a little older than Melania Trump recently had a nephrectomy on suspicion of cancer, the kidney was removed by hand assisted laprascopic surgery and two days later she went home and was back at work inside two weeks. She was fortunate that the biopsy on thesizeable tumor in the removed kidney it was found to be currently benign and no further medical action or treatment was required.

.
Regards,
     Greg_L-W
Greg Lance-Watkins
.
 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving my wife Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.

If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings. . Later in the sequence of my experiences with cancer you will note that I introduce some results and events most probably linked with cancer such as enlarged & damaged Prostate and a consequential Heart Attack leaving me with no right coronary artery! . I have also included numerous articles and anecdotes regarding health – primarily related to cancer, prostate and heart conditions – FYI! . Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar. . You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
.
YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help you in ANY way. .

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
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Posted by: Greg Lance-Watkins
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#Stephen_Fry’s Own Words Regarding His Recent Diagnosis With #Prostate_Cancer & His Chosen Treatment …

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#Stephen_Fry’s Own Words Regarding His Recent Diagnosis With #Prostate_Cancer & His Chosen Treatment …
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Greg_L-W

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 .

Hi,

first may I wish Stephen Fry a speedy and full recovery from the actions he and his Oncology Consultant decided to take when he had been diagnosed to have Prostate Cancer.

Do listen to Stephen Fry’s story in his own words and if you need more information on Prostate Cancer just put >prostate cancer< in the >SEARCH BOX< at the top of the >Right Sidebar< on this web site and follow the links.

Here is a film of the Robotic operating machine Stephen Fry spoke of, it is commonly known as a Da Vinci Machine and is operated by a surgeon or trained operator remotely via a VDU:

.
Regards,
     Greg_L-W
Greg Lance-Watkins
.
 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving my wife Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.

If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings. . Later in the sequence of my experiences with cancer you will note that I introduce some results and events most probably linked with cancer such as enlarged & damaged Prostate and a consequential Heart Attack leaving me with no right coronary artery! . I have also included numerous articles and anecdotes regarding health – primarily related to cancer, prostate and heart conditions – FYI! . Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar. . You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
.
YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help you in ANY way. .

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
.
Posted by: Greg Lance-Watkins
tel: 44 (0)1594 – 528 337
Calls from ‘Number Withheld’ phones Are Blocked

All unanswered messages are recorded.
Leave your name & a UK land line number & I will return your call.

‘e’Mail Address: Greg_L-W@BTconnect.com

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.Follow Greg_LW on Twitter.

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Delaying The Death Of Charlie Gard …

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Delaying The Death Of Charlie Gard …

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Posted by:
Greg Lance – Watkins
Greg_L-W

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Hi,

I am pleased to note that the obscene point scoring of the likes of The Papacy, Donald Trump and others as they interfered with the treatment of Charlie Gard, for their own gain, contra the sound advice of medical experts and the center of excellence Great Ormond Street Children’s Hospital – Charlie Gard’s death will now be permitted with no further experimentation & artificial extension.

Common sense & common decency prevailed in the end though Charlie Gard has been dead, in real terms since December, sustained mechanically, with no knowledge of just what he was suffering, besides gross indignity!

 

demtrsnxuaev7io Britain USA 

A cruel and ignorant campaign

The agonising case of Charlie Gard, the 11-month old baby dying from a rare form of mitochondrial disease, is edging towards a no less agonising conclusion.

Today, his parents agreed that he should be transferred from Great Ormond Street hospital in London (GOSH) to a hospice to spend there his final period of life.

The hospice was a compromise. The parents have been fighting the plan for their baby’s end of life care just as they had fought the decision that he should no longer be kept alive. They wanted to bring Charlie home to die. The hospital refused to agree because of the difficulties of providing the particular ventilation and other procedures for Charlie at home, and the potential for causing him yet more distress or even causing him to die before he got home.

The court that has been attempting to arbitrate this heartbreaking dispute has set a deadline of noon tomorrow for the parents to find a team that can support Charlie for the days the parents want to spend with him at the hospice. Otherwise he will be taken off his life support shortly after being transferred.

The parents deserve only the most profound sympathy. Their unremitting rage at the hospital has to be seen in the context of mind-altering grief. In such a state, however, it is sometimes not possible to make decisions that really are in the best interests of their child. In this case, moreover, it is impossible to avoid the conclusion that their stress has been hugely compounded by one of the most cruelly ill-conceived campaigns of recent times.

The parents finally agreed to allow Charlie to die having seen from his most recent scan and the opinion of American neurologist Professor Michio Hirano, whose experimental nucleoside treatment (NBT) they hoped would save him, that any such treatment was hopeless. Yet in her emotional statement to the court Charlie’s mother Connie Yates implied that if he had been treated earlier he could have been saved.

Clearly, no-one can ever know if that might have been so. But what we do know is that at no stage was any credible evidence brought forward to show that Charlie’s brain damage was not irreversible, as the hospital told the parents it was months ago, so much so that any further treatment was futile. Nor was there ever any evidence during this time that Professor Hirano’s or any other treatment would ameliorate his condition.

The statement put out by the hospital after Ms Yates’s emotional words is worth reading in full. It addressed head on the key questions posed by the parents and their supporters: why not give Charlie at least the chance of further treatment? What did he have to lose? And if he had been treated months ago, would this terrible situation have been avoided?

In its answer, the hospital noted once again that no animal or human with Charlie’s precise disease had even been treated by NBT. After Charlie had suffered seizures before last Christmas, the entire treating team formed the view that Charlie had suffered irreversible neurological damage and that, as a result, any chance of benefit from this treatment had departed.

Charlie’s parents, however, refused to believe his brain was damaged. There lay the root of the problem. For do all these people demonstrating outside the court and shrieking that Great Ormond Street hospital were “murderers”, or writing ignorant and intemperate op-eds in the American media declaring that only the parents had the right to decide what was in the best interests of their child, really believe that parents know better than neurologists about damage that has been done to the brain?

The hospital statement contains two particularly devastating passages. The first leaves the reputation of Professor Hirano in shreds.

“Professor Hirano (“the Professor”), whose laboratory research has an international reputation, is very well known to the experts at GOSH and he communicated with them about NBT treatment for Charlie at the very end of December. In January, GOSH invited the Professor to come and see Charlie. That invitation remained open at all times but was not taken up until 18 July after being extended, once again, this time by the Court.

“When the hospital was informed that the Professor had new laboratory findings causing him to believe NBT would be more beneficial to Charlie than he had previously opined, GOSH’s hope for Charlie and his parents was that that optimism would be confirmed.”

That claim of new research evidence was why the parents returned to court and re-opened the case. The judge said he was eager to hear of this new evidence and hoped it would enable him to reverse his previous ruling. The GOSH statement, however, continues:

“It was, therefore, with increasing surprise and disappointment that the hospital listened to the Professor’s fresh evidence to the Court. On 13 July he stated that not only had he not visited the hospital to examine Charlie but in addition, he had not read Charlie’s contemporaneous medical records or viewed Charlie’s brain imaging or read all of the second opinions about Charlie’s condition (obtained from experts all of whom had taken the opportunity to examine him and consider his records) or even read the Judge’s decision made on 11 April.

“Further, GOSH was concerned to hear the Professor state, for the first time, whilst in the witness box, that he retains a financial interest in some of the NBT compounds he proposed prescribing for Charlie. Devastatingly, the information obtained since 13 July gives no cause for optimism. Rather, it confirms that whilst NBT may well assist others in the future, it cannot and could not have assisted Charlie.”

In other words, there never was any hope for Charlie – and the claim that
fresh research evidence provided some new hope was wholly without foundation and came from someone who had never even examined the child.

But here’s the really wicked thing about all this. The parents were reinforced in their refusal to accept this tragic situation, and the whole court process pointlessly prolonged, because of the pressure largely emanating from activists and media on the American political right (along with right-to-life campaigners) screaming that a baby was about to be killed by a socialised health care “death panel” enforced by the British government. This campaign led the parents to believe that such pressure could change the court’s mind. And so the parents were reinforced in their refusal to face reality.

The commentary emanating from America, however, was staggeringly ill-informed. The website American Thinker, for example, ran one hysterical piece after another. Thus the case represented “a perfect crystallization of the full heart and soul of socialized or ‘single payer’ health care”, a “tyrannically impersonal “medical system” in which “the individual human being is property of the State”.

“Little Charlie Gard appears to be under a death sentence courtesy of Great Ormond Street Hospital and the British Courts” in “a totalitarian state where the courts decide whether my child can live or die, where they can withhold medical treatment as and when they decide, where they can prevent treatment in another nation, where the rights of the individuals involved can be thrown on the floor and trashed like so much refuse”

…“the almost inhuman indifference to the plight of the parents by the Great Ormond Street Hospital, who insist that the parents should have no hope of improvement in their son and acquiesce in his death”…

“progressive death cult according to which individual lives are mere variables in an abstract calculus based on social utility and budgetary value.” And so on, and on.

On Liberty Unyielding, a writer decided that the case reflected the belief she thought was expressed by a British ethicist that “the authority of government over human life is itself a first principle, so inviolable that everything else must yield to it.”

Even the normally intelligent Wall Street Journal decried “a system that elevated a judge’s opinion about what was best for Charlie over loving parents. Few should be surprised, because the brutal reality is that when the state is responsible for nearly all health spending it inevitably takes responsibility for life and death decisions too.”

But this case had absolutely nothing to do with the state or the government. This was not Charlie’s parents v the state. This was Charlie’s parents v the medical profession, a conflict in which the courts were brought in as the dispassionate arbiter in the best interests above all of the sick child.

This was another thing the American commentators seemed incapable of grasping. In the US, the courts are highly politicised with judicial figures appointed by the state. But in Britain the courts are truly independent, representing law and justice. The state does not tell the British courts what to do; the British courts in fact hold the state to account. So the idea that the courts were enforcing state diktat in this case was totally ridiculous.

Nor had this anything to do with “socialised medicine” or the NHS system. This was purely a case where doctors were making decisions absolutely in line with medical ethics, which hold that causing a patient any pain or distress from treatment is only permissible if there is clear benefit to the patient from that treatment. In this case, there was not.

And this fact was reflected in the most devastating passage in the hospital’s statement.

“At the first hearing in Charlie’s case in March, GOSH’s position was that every day that passed was a day that was not in his best interests. That remains its view of his welfare. Even now, Charlie shows physical responses to stressors that some of those treating him interpret as pain and when two international experts assessed him last week, they believed that they elicited a pain response.

“In GOSH’s view there has been no real change in Charlie’s responsiveness since January. Its fear that his continued existence has been painful to him has been compounded by the Judge’s finding, in April, that since his brain became affected by RRM2B [his genetic disease] , Charlie’s has been an existence devoid of all benefit and pleasure. If Charlie has had a relationship with the world around him since his best interests were determined, it has been one of suffering.”

That is the most terrible point of all. Charlie may have been in pain and distress. That above all was the hospital’s fear; that above all weighed particularly heavily on the judge’s mind. If that was indeed so, then every day this case has dragged on has meant that this sick baby might have been caused yet more suffering.

If so, the parents in their great distress cannot be blamed. The people who should consider what harm they may have done here are all those who, through giving the parents such false hopes, so cruelly embedded them in their denial of reality.

Whether or not Great Ormond Street hospital was right or wrong in its diagnosis, its medical staff were only ever concerned with one thing: the best interests of their tiny patient. For this they have been subjected to vilification and death threats and portrayed as inhumane and murderers. This is unspeakable.

I write a great deal about the ideological bullying of the left, the lies published by left-wing media and the inhumanity and irrationality of so much allegedly progressive thinking. But I have never witnessed such concentrated ignorance, arrogance, stupidity and unthinking cruelty as has been displayed by the American political right over the tragic case of Charlie Gard.

The last word should be given to Great Ormond Street hospital:

“All of GOSH’s thoughts go with Charlie and his mother and father – the hospital wishes each of them peace in their hearts at the end of this day and each day to come”.

To view Melanie Phillips’ Original Article CLICK HERE
.
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     Greg_L-W
Greg Lance-Watkins
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‘Fingerprint’ in the blood is linked to prostate cancer risk …

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‘Fingerprint’ in the blood is linked to prostate cancer risk

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Hi,

‘Fingerprint’ in the blood is linked to prostate cancer risk

05 July 2017 | News, Science and research

Dr Travis leads a research project that we fund at the University of Oxford.

My current project is exploring a new field of research that has the potential to uncover ways of preventing prostate cancer through improved diet and lifestyle.

Prostate cancer is the most common cancer in British men, so this research is incredibly important and it would not be possible without the support of World Cancer Research Fund.

What the study found

This new area of research is known as metabolomics and it measures small molecules in the blood called metabolites.

Our study found that the levels of different metabolites that make up a man’s metabolic ‘fingerprint’ in the blood were linked with his risk of developing prostate cancer.

How does this relate to my daily life?

The levels of different metabolites present in someone’s blood are partly determined by diet and lifestyle. This means that the ‘fingerprint’ of metabolites in the blood could give us new insights into how diet and lifestyle can affect prostate cancer risk.

The next stage of the project will focus on working out precisely how diet and lifestyle factors can affect the pattern of metabolites in the blood. This will help us achieve our ultimate aim of fully understanding how diet and lifestyle can help prevent prostate cancer.

Making a difference

There is already strong evidence that maintaining a healthy weight is associated with a reduced risk of aggressive types of prostate cancer.

However, if more risk factors for prostate cancer are uncovered, this could help us prevent many more cases, particularly the more aggressive types.

To view the original article CLICK HERE

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Regards,
     Greg_L-W
Greg Lance-Watkins
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 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
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I just want to say sorry for copping out at times and leaving my wife Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.

If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings. . Later in the sequence of my experiences with cancer you will note that I introduce some results and events most probably linked with cancer such as enlarged & damaged Prostate and a consequential Heart Attack leaving me with no right coronary artery! . I have also included numerous articles and anecdotes regarding health – primarily related to cancer, prostate and heart conditions – FYI! . Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar. . You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
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YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help you in ANY way. .

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
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Posted by: Greg Lance-Watkins
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Nivolumab & Ipilimumab Immunotherapy Is A Kidney Cancer Game Changer

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Nivolumab & Ipilimumab Immunotherapy Is A Kidney Cancer Game Changer
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Posted by:
Greg Lance – Watkins
Greg_L-W

eMail: Greg_L-W@BTconnect.com

~~~~~~~~~~#########~~~~~~~~~~

Hi,

Immunotherapy cancer drug hailed as ‘game changer’

  • 9 October 2016
 Kidney cancer
Image copyright Science Photo Library

An immunotherapy drug has been described as a potential “game-changer” in promising results presented at the European Cancer Congress.

In a study of head and neck cancer, more patients taking nivolumab survived for longer compared with those who were treated with chemotherapy.

In another study, combining nivolumab with another drug shrank tumours in advanced kidney cancer patients.

Immunotherapy works by harnessing the immune system to destroy cancer cells.

Advanced head and neck cancer has very poor survival rates.

In a trial of more than 350 patients, published in the New England Journal of Medicine, 36% treated with the immunotherapy drug nivolumab were alive after one year compared with 17% who received chemotherapy.

Patients also experienced fewer side effects from immunotherapy.

Double hit

The benefits were more pronounced in patients whose tumours had tested positive for HPV (human papillomavirus). These patients survived an average of 9.1 months with nivolumab and 4.4 months with chemotherapy.

Normally, this group of patients are expected to live less than six months.

Early data from a study of 94 patients with advanced kidney cancer showed that the double hit of nivolumab and ipilimumab resulted in a significant reduction in the size of tumours in 40% of patients.

Of these patients, one in 10 had no sign of cancer remaining.

This compares with 5% of patients showing tumour reduction after standard therapy.

About 12,000 people are diagnosed with kidney cancer in the UK each year and an average of 12 people die from the disease each day.

Image caption Peter Waite was able to continue working as a motor technician while receiving immunotherapy treatment for cancer
Peter Waite, cancer patient

Peter’s journey

“I feel a bit of a fraud having terminal cancer because I haven’t been in pain at all,” says Peter Waite, 64, from Hertfordshire.

“There’s been nothing negative about it for me and I feel a bit embarrassed really.”

Peter started receiving combined immunotherapy (nivolumab and ipilimumab) in a clinical trial in early 2015 after doctors discovered he had a type of renal cancer several years after recovering from kidney and lung cancer.

He was told he probably had three to five years left.

Instead of being treated with chemotherapy, he spent four months receiving both immunotherapy drugs and experienced virtually no side effects, allowing him to continue working as a motor technician throughout his treatment.

Scans of his kidney and lungs show that one of his tumours has shrunk and two others have not shown any further growth.

He is no longer taking the drugs and is being monitored every 12 weeks with scans.

Mr Waite said his daughters have teased him about being a guinea pig – and considered buying him some hay.

“I’m a very upbeat sort of bloke and I’ve been very lucky,” he says.

“I feel very privileged to have had the opportunity to go on the trial.”

As yet, nivolumab has only been approved for treating skin cancer and in June it became one of the fastest medicines ever approved for NHS use, in combination with ipilimumab, for the same cancer.

Nivolumab and ipilimumab both work by interrupting the chemical signals that cancers use to convince the immune system they are healthy tissue.

‘Extend life’

Prof Kevin Harrington of the Institute of Cancer Research and consultant at the Royal Marsden Hospital in London, who led the head and neck cancer trial, said nivolumab could be a real “game changer” for patients with advanced head and neck cancer.

“This trial found that it can greatly extend life among a group of patients who have no existing treatment options, without worsening quality of life.

“Once it has relapsed or spread, head and neck cancer is extremely difficult to treat. So it’s great news that these results indicate we now have a new treatment that can significantly extend life, and I’m keen to see it enter the clinic as soon as possible.”

Prof Paul Workman, chief executive of The Institute of Cancer Research, said nivolumab was one of a new wave of immunotherapies that were beginning to have an impact across cancer treatment.

He added: “We hope regulators can work with the manufacturer to avoid delays in getting this drug to patients who have no effective treatment options left to them.”

To view the original of this article CLICK HERE

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
Posted by: Greg Lance-Watkins
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New target discovered for kidney cancer therapy

New target discovered for kidney cancer therapy
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Kidney and blader 1200 resolution 612KB
New target discovered
for kidney cancer therapy

Last updated: 12 November 2014 at 12am PST

Cancer / Oncology
Urology / Nephrology

Cincinnati Cancer Center (CCC) researchers have discovered that a membrane channel, Transient Receptor Potential Melastatin 3, or TRPM3, promotes growth of kidney cancer tumors, and targeting this channel therapeutically could lead to more treatments for a disease that currently has few treatment options.

A membrane channel is a family of proteins that allows the movement of ions, water or other solutions to pass through the membrane.

These findings were published in the journal Cancer Cell.

“Metastatic clear cell kidney cancer is largely incurable, and existing treatments for the disease are only minimally effective,” says Maria Czyzyk-Krzeska, MD, PhD, senior author of the study, member of the CCC and the University of Cincinnati (UC) Cancer Institute and professor in UC’s department of cancer biology. “Our team found a new target in kidney cancer known as TRPM3. TRPM3 is increased in 60 percent of kidney clear cell carcinomas where it promotes growth of tumors by stimulating intracellular pathways that initiate autophagy – a quality control process in cancer cells that also generates intracellular nutrients.

“During tumor growth, cancer cells become addicted to autophagy as a source of nutrients. Furthermore, autophagy contributes to chemotherapy resistance in kidney cancer. The new target we’ve identified regulates kidney cancer cell autophagy.”

The experiments were conducted using animal models, human cell cultures and tumor specimens. The researchers analyzed expression of the channel, its effect on tumor growth and on autophagy and how regulation of autophagy contributed to tumor growth.

“Our discovery of a TRPM3 stimulated network in the regulation of autophagy and kidney cancer growth could lead to use of the channel as a new actionable target in renal cancer. There are already FDA-approved TRPM3 inhibitors on the market, so this is quite promising,” Czyzyk-Krezeska says.

To view the original of this article  CLICK HERE
.
Regards,
Greg_L-W.
.
 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.
If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings.
.
Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar.
.
You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
.
YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help in ANY way. .

Posted by: Greg Lance-Watkins

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