Fecal Transplant Pills Could Become a New Cutting-Edge Treatment for Infections …

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Fecal Transplant Pills
Could Become a New Cutting-Edge Treatment for Infections …
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Greg Lance – Watkins
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Hi,

many of you, if not most of you, who have visited a family member or friend in hospital, and particularly those of you who have had any long term exposure to hospital will be well aware of the prevalence of outbreaks of C/ difficile, Nora Virus and the like that lead to ward closures, isolation and all too often deaths.

These outbreaks are not only concerning but costly but this new cutting-edge treatment may well be the answer to the problem and may even act as a guard against the problem if administered as a routine on admission!

There is some belief that as a benefit of our evolutionary background as scavengers, hunters and gatherers the appendix have functioned as a holding point for gut flora/bacteria. A point that can hold a resevoir of vital bacteria, that can repopulate the gut after a sever stripping of its content by the likes of C.diff.

I wonder if such capsules could be used to introduce such as live Rennet to aleviate some cases of lactose intollerance?

Getty Images
By Alice Park

November 28, 2017

Human waste has long been thought of as just that: everything the body doesn’t want or need. But new research is showing that feces may contain valuable organisms that can actually treat disease.

In a new paper published in JAMA, researchers led by Dr. Dina Kao, a gastroenterologist at the University of Alberta in Canada, and her colleagues report that fecal matter manufactured into a capsule was no worse than fecal matter transplanted by colonoscopy. Both procedures successfully reduced risk of repeated C. difficile infections by more than 90%. C. difficile (C. diff) infections can be caused by bacteria that are resistant to many antibiotics.

The advantages of a capsule over a colonoscopy, which is an invasive procedure that requires mild sedation, are clear. Any time people are sedated, there is a risk that their breathing will slow too much. Colonoscopy also comes with the risk of puncturing the intestinal wall, which can introduce infections that could be life threatening. The benefits of swallowing a capsule are also undeniable compared to swallowing — or trying to swallow — a feeding tube through which a slurry of fecal matter is flowing through. (That’s the way that doctors testing fecal transplants originally administered their doses.) That carries the risk of aspirating some of the fecal slurry into the lungs — not to mention the unpleasantness of introducing feces to the mouth area and accidentally breathing it in.

Fecal transplants are part of the burgeoning field of research involving the microbiome: the living universe of microbes, including bacteria, that live on and in the body. Unlike their disease-causing counterparts, these microbes work to improve human health. Certain bacteria, for example, are linked to lower rates of conditions like allergies, asthma, obesity and even some types of mental illnesses.

Studies have found that certain microbes in the digestive tract are linked to lower rates of C. difficile infection, which is mainly acquired in health care settings like hospitals and nursing homes. About 90% of people who receive fecal transplant by colonoscopy do not experience recurrent infections. Antibiotics can treat the infection, but anywhere from 10% to 30% of people will develop further infections, and each recurrence increases the risk of another one.

While certain microbiome populations can lower the risk of infection, it’s not clear whether the amount of bacteria in the gut is the key factor, or whether it’s the type of bacteria or even how the bacteria is delivered. In the study, Kao focused on understanding whether the way the gut bugs are delivered makes a difference. “The biggest question in this area has always been, what’s the best way to deliver the transplant?” she says. “I think with this study, we can see that maybe the capsule delivery format is the way to go if you are going to give this type of microbiome-based therapy.”

MORE:Fecal Transplants May Soon Be Available in a Pill

All 116 people in the study had experienced at least three cases of C. difficile infection. They were randomly assigned to receive a fecal transplant by either capsules or a colonoscopy. The people taking the capsules had to swallow 40 of them in a single sitting, usually over 30 minutes to an hour. After 12 weeks, about 90% of people in each group remained free of additional infections.

That’s encouraging for patients who struggle with a poor quality of life while battling recurrent infections, which cause serious diarrhea several times a day along with severe cramping and dehydration. “Based on this study, I think it would be very reasonable to think about fecal transplant capsules as your preferred approach,” says Dr. Preeti Malani, professor of medicine at the University of Michigan, who wrote an editorial accompanying the study. “If it were myself or a family member, I think avoiding colonoscopy would be helpful.” She also notes that most people who have repeated infections are older, frail and in poor health, which makes an invasive procedure like colonoscopy riskier.

MORE:Here’s Why Europe Is Supporting Fecal Transplants

But she also says that more studies are needed — first, to confirm the results that Kao found, and second, to better understand how the fecal transplant process works. One question is whether the bacteria are actually responsible for controlling the infection. A previous study found that a fecal sample that was sterilized to kill all the bacteria still resulted in fewer repeat infections, raising the question of whether there is something else in fecal matter that is beneficial. If bacteria are responsible, which bacteria are best, and how much are needed to treat the infection? These unanswered questions are why the Food and Drug Administration has not yet approved fecal transplants, but does allow doctors to apply for permission to perform them to treat people with C. difficile that does not respond to other therapies — as long as the patient is aware the transplant is still in the testing phases.

Kao is planning on studying the components of the fecal transplant to better understand what is helping to control the C. difficile.

In the meantime, while the idea of swallowing a capsule of poop may seem unpleasant, it may be the best way yet to control an otherwise devastating infection. When Kao asked the people in the study to rate their experience, more people taking the capsules than the colonoscopy said the process was “not at all unpleasant.”

To view the original article CLICK HERE

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     Greg_L-W
Greg Lance-Watkins
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HEADS UP Its Your Turn For A COLONOSCOPY Next!

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HEADS UP Its Your Turn For A COLONOSCOPY Next!
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Posted by:
Greg Lance – Watkins
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Hi,

HEADS UP Its Your Turn For A COLONOSCOPY Next!
DON’T COUGH!

having had rather more intrusive inspections, treatments and operations than I would wish on all but a very few people – though so far I am pleased to say NOT a Colonoscopy YET – I was able to empathise entirely with this article.

I am something of an expert at enduring flexible colposcopy for the urinary bladder having bladder cancer! Also when it comes to purgative procedures both by stealth, as with diclosure medicaments for various scans and X-Rays which no one warns you about! to the fact that they want the gut empty for major organ surgery (in my case a radical nephrectomy 05-Sep-2001) – so that IF they puncture the gut they have a rather less toxic problem to deal with!

Those of you who have had abdominal surgery will appreciate the fetishistic obsession Consultants, Surgeons, Doctors, Sisters & Nurses have with flatulence! This is not, as some think, a grown up medical extention of childish ‘Fart Jokes’ which seem to be the basis of idiot humour until 9pm. on TV and then it just uses obscene language for the same jokes – as with the crass and tedious Jonathan Ross.

The truth is that the entire medical profession is deeply deeply worried due to an excess of management and QUANGOs, Politicians and Management Consultancies – it is essential that they ensure that they have reconnected the gut the right way around as they really don’t want to make any more managers or politicians 😉

I hope you find the informative article that follows as amusing as I did – I guess its called empathy!

Colonoscopy

If you’ve had one you’ll understand and if you haven’t – your time is coming!

This is from newshound Dave Barry’s colonoscopy journal:

“I called my friend Andy Sable, a gastroenterologist, to make an appointment for a colonoscopy. A few days later, in his office, Andy showed me a colour diagram of the colon, a lengthy organ that appears to go all over the place, at one point passing briefly through Minneapolis .

Then Andy explained the colonoscopy procedure to me in a thorough, reassuring and patient manner. I nodded thoughtfully, but I didn’t really hear anything he said, because my brain was shrieking, quote, ‘HE’S GOING TO STICK A TUBE 17,000 FEET UP YOUR BEHIND!’

I left Andy’s office with some written instructions, and a prescription for a product called ‘MoviPrep,’ which comes in a box large enough to hold a microwave oven. I will discuss MoviPrep in detail later; for now suffice it to say that we must never allow it to fall into the hands of America’s enemies.

I spent the next several days productively sitting around being nervous. Then, on the day before my colonoscopy, I began my preparation.

In accordance with my instructions, I didn’t eat any solid food that day; all I had was chicken broth, which is basically water, only with less flavour. Then, in the evening, I took the MoviPrep.

You mix two packets of powder together in a one-litre plastic jug, then you fill it with lukewarm water. (For those unfamiliar with the metric system, a litre is about 32 gallons.) Then you have to drink the whole jug.

This takes about an hour, because MoviPrep tastes – and here I am being kind – like a mixture of goat spit and urinal cleanser, with just a hint of lemon.

The instructions for MoviPrep, clearly written by somebody with a great sense of humour, state that after you drink it, ‘a loose, watery bowel movement may result.’ This is kind of like saying that after you jump off your roof, you may experience contact with the ground.

MoviPrep is a nuclear laxative. I don’t want to be too graphic, here, but: Have you ever seen a space-shuttle launch? This is pretty much the MoviPrep experience, with you as the shuttle. There are times when you wish the toilet had a seat belt. You spend several hours pretty much confined to the bathroom, spurting violently. You eliminate everything. And then, when you figure you must be totally empty, you have to drink another litre of MoviPrep, at which point, as far as I can tell, your bowels travel into the future and start eliminating food that you have not even eaten yet.

After an action-packed evening, I finally got to sleep. The next morning my wife drove me to the clinic. I was very nervous. Not only was I worried about the procedure, but I had been experiencing occasional return bouts of MoviPrep spurtage. I was thinking, ‘What if I spurt on Andy?’ How do you apologize to a friend for something like that? Flowers would not be enough.

At the clinic I had to sign many forms acknowledging that I understood and totally agreed with whatever the heck the forms said. Then they led me to a room full of other colonoscopy people, where I went inside a little curtained space and took off my clothes and put on one of those hospital garments designed by sadist perverts, the kind that, when you put it on, makes you feel even more naked than when you are actually naked.

Then a nurse named Eddie put a little needle in a vein in my left hand.

Ordinarily I would have fainted, but Eddie was very good, and I was Already lying down. Eddie also told me that some people put vodka in their MoviPrep. At first I was ticked off that I hadn’t thought of this, but then I pondered what would happen if you got yourself too tipsy to make it to the bathroom, so you were staggering around in full Fire Hose Mode. You would have no choice but to burn your house.

When everything was ready, Eddie wheeled me into the procedure room, where Andy was waiting with a nurse and an anaesthetist. I did not see the 17,000-foot tube, but I knew Andy had it hidden around there somewhere.
I was seriously nervous at this point. Andy had me roll over on my left side, and the anaesthetist began hooking something up to the needle in my hand. There was music playing in the room, and I realized that the song was ‘Dancing Queen’ by ABBA. I remarked to Andy that, of all the songs that could be playing during this particular procedure, ‘Dancing Queen’ had to be the least appropriate.

‘You want me to turn it up?’ said Andy, from somewhere behind me. ‘Ha ha,’ I said. And then it was time, the moment I had been dreading for more than a decade. If you are squeamish, prepare yourself, because I am going to tell you, in explicit detail, exactly what it was like.

I have no idea. Really. I slept through it. One moment, ABBA was Yelling ‘Dancing Queen, feel the beat of the tambourine,’ and the next moment, I was back in the other room, waking up in a very mellow mood.

Andy was looking down at me and asking me how I felt. I felt excellent. I felt even more excellent when Andy told me that It was all over, and that my colon had passed with flying colours. I have never been prouder of an internal organ.

ABOUT THE WRITER

Dave Barry is a Pulitzer Prize-winning humour columnist for the MiamiHerald.


On the subject of Colonoscopies…
Colonoscopies are no joke, but these comments during the exam were quite humorous….. A physician claimed that the following are actual comments made by his patients (predominately male) while he was performing their colonoscopies:

1. ‘Take it easy, Doc. You’re boldly going where no man has gone before!

2. ‘Find Amelia Earhart yet?’

3. ‘Can you hear me NOW?’

4. ‘Are we there yet? Are we there yet? Are we there yet?’

5. ‘You know, in Arkansas , we’re now legally married.’

6. ‘Any sign of the trapped miners, Chief?’

7. ‘You put your left hand in, you take your left hand out…’

8. ‘Hey! Now I know how a Muppet feels!’

9. ‘If your hand doesn’t fit, you must quit!

10. ‘Hey Doc, let me know if you find my dignity.’

11. ‘You used to be an executive at Enron, didn’t you?’

12. “Now I know why I am not gay.’

And the best one of all.

13. ‘Could you write a note for my wife saying that my head is not up there?’

To view a colonoscopy CLICK HERE
Regards,
Greg L-W.
01291 – 62 65 62

Regards,
Greg_L-W.

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