#Canakinumab Is Clearly The New Wonder Drug For Patients With #Heart_Attacks …

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#Canakinumab Is Clearly The New Wonder Drug For Patients With #Heart_Attacks …

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Best heart drug since statins: New injection could save thousands of lives by preventing heart attacks and also slash cancer risk

  • Landmark four-year trial found Canakinumab  cut heart attack risk by 24 per cent
  • The study also suggested it could halve the risk of dying from lung cancer
  • Scientists have hailed the find and said treatment could save thousands of lives 
A breakthrough drug could prevent thousands of heart attacks (stock picture)

A breakthrough drug could prevent thousands of heart attacks (stock picture)

Thousands of lives could be saved thanks to a new heart drug hailed as the biggest breakthrough since statins.

In a landmark four-year trial, scientists found that the drug – given by injection every three months – cut the risk of heart attacks by a quarter.

The 10,000-patient study, involving 1,000 doctors in 39 countries, also suggested it could halve the risk of dying from lung cancer and prevent arthritis and gout.

Scientists last night said the treatment marked ‘a new era of therapeutics’ that could save thousands of lives.

The drug, Canakinumab, works by reducing inflammation – a major new approach in heart medicine.

For the past 30 years cholesterol-busting statins have been given to nearly all people deemed to be at risk of cardiovascular disease in a bid to save them from heart attacks and strokes. Yet half of the 200,000 people who have a heart attack in Britain each year do not have high cholesterol, meaning there is a desperate need for a different approach to treatment.

Experts have long thought that inflammation – the body’s natural responses to infection or injury – might also play a major role in causing heart attacks and strokes, possibly because it causes the condition to flare in the arteries, increasing the risk of a blockage.

In a landmark four-year trial, scientists found that the drug - given by injection every three months – cut the risk of heart attacks by 24 per cent (stock picture)

 

In a landmark four-year trial, scientists found that the drug – given by injection every three months – cut the risk of heart attacks by 24 per cent (stock picture)

The new trial, however, is the first definitive proof that cutting inflammation slashes heart risk.

Study leader Professor Paul Ridker of Harvard Medical School said the new drug opened up a ‘third front’ in the war on heart disease, following the previous focus on cholesterol and lifestyle.

Presenting his findings at the European Society of Cardiology congress in Barcelona yesterday, Prof Ridker said: ‘These findings represent the end game of more than two decades of research, stemming from a critical observation – half of heart attacks occur in people who do not have high cholesterol.

‘For the first time, we’ve been able to definitively show that lowering inflammation independent of cholesterol reduces cardiovascular risk.’

Prof Ridker, whose results are published in the New England Journal of Medicine, added: ‘This has far-reaching implications.

Ease back on salt 

Eating too much salt more than doubles the risk of heart failure, scientists have found.

Experts have long known that salt increases high-blood pressure – but the new research suggests it also does direct damage to the heart.

Researchers at the National Institute for Health and Welfare in Helsinki tracked 4,630 healthy adults for 12 years.

They found 20 per cent of people were eating more than 13.7g daily. The UK guideline is 6g.

These people were twice as likely to suffer heart failure than those who ate less than 6.8g. Lead researcher Professor Pekka Jousilahti said: ‘The heart does not like salt. High salt intake markedly increases the risk of heart failure.’

 

‘It tells us that by leveraging an entirely new way to treat patients – targeting inflammation – we may be able to significantly improve outcomes for certain very high-risk populations.’

Canakinumab is an antibody that attacks an immune-system protein called interleukin-1, which in high levels results in increased inflammation throughout the body.

The trial involved high-risk patients who had already suffered a heart attack – a group in desperate need of help because a quarter of patients suffer a second attack within five years, even with statins.

All patients in the trial took statins as well, but the research team found the addition of Canakinumab cut the risk of repeat heart attacks by 24 per cent, over and above the impact of the cholesterol drug.

People who took the drug were also 36 per cent less likely to be hospitalised with unstable angina, and 32 per cent less likely to require expensive interventional procedures such as bypass surgery.

Researchers reported a sharp rise in infections – a side effect linked to the fact inflammation protects against infection – which killed one in every 1,000 patients.

But they also found patients had a 51 per cent reduced risk of lung cancer deaths – a finding they said was ‘very exciting’ and needed further trials. Gout and arthritis, which are linked to inflammation, also fell.

Drugs giant Novartis, which makes Canakinumab, said it would immediately apply for a medical licence to use the drug for heart disease.

All patients in the trial took statins as well, but the research team found the addition of Canakinumab cut the risk of repeat heart attacks by 24 per centAll patients in the trial took statins as well, but the research team found the addition of Canakinumab cut the risk of repeat heart attacks by 24 per cent

Canakinumab is used for inflammatory problems, including rare forms of arthritis, at the cost of £9,928 per jab. It is expensive because the conditions are rare, so sales are low. Experts said the price – £40,000 a year for heart patients – would have to come down if it were to be made available on the NHS.

Professor Jeremy Pearson, of the British Heart Foundation, said: ‘These exciting and long-awaited trial results finally confirm that ongoing inflammation contributes to risk of heart disease, and could help save lives.’

American cardiologist Steven Nissen said: ‘This is as big as anything we’ve seen in a while. It’s a gateway to a very wide variety of therapies that are going to be developed.’

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     Greg_L-W
Greg Lance-Watkins
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Heart attack and cancer deaths could be cut by a new drug …

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Heart attack and cancer deaths could be cut by a new drug …

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Posted by:
Greg Lance – Watkins
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Hi,

Heart attack and cancer deaths could be cut by new drug

A study on an anti-inflammatory shows a 15% reduction in heart attack risk and the number of cancer deaths cut by half.

Stock photo ID:627196908
Upload date:January 04, 2017
Image: Results of the trial have been described as ‘very exciting’

A new drug that could help reduce the risk of heart attacks and cut cancer deaths has been hailed as an “exciting” breakthrough.

Canakinumab, an anti-inflammatory, was used in a trial involving more than 10,000 patients, all of whom have had a heart attack but had not been diagnosed with cancer.

 

They were treated with the drug, which is given by injection, once every three months and monitored for up to four years.

The study showed a 15% reduction in the risk of heart attacks and strokes and the number of cancer deaths cut by half.

One of the researchers, Dr Paul Ridker of Brigham and Women’s Hospital in Boston, said the findings have “far-reaching implications”.

He said: “For the first time, we’ve been able to definitively show that lowering inflammation independent of cholesterol reduces cardiovascular risk.

“It tells us that by leveraging an entirely new way to treat patients – targeting inflammation – we may be able to significantly improve outcomes for certain very high-risk populations.”

The benefits seen in the patients were “above and beyond” those seen in patients who just took statins, the hospital said.

Dr Ridker said: “In my lifetime, I’ve gotten to see three broad eras of preventative cardiology.

“In the first, we recognised the importance of diet, exercise and smoking cessation. In the second, we saw the tremendous value of lipid-lowering drugs such as statins. Now, we’re cracking the door open on the third era.

“This is very exciting.”

Regarding the cancer findings, Dr Ridker said more research was needed but there was the “possibility of slowing the progression of certain cancers”.

Gary Gibbons, director of the National Heart, Lung, and Blood Institute, said: “Although this trial provides compelling evidence that targeting inflammation has efficacy in preventing recurrent cardiovascular events, we look forward to findings from additional trials, such as the NHLBI-funded Cardiovascular Inflammation Reduction Trial, to further refine the best therapeutic strategies for preventing cardiovascular disease.”

To see the original of this article CLICK HERE
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Regards,
     Greg_L-W
Greg Lance-Watkins
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 Please Be Sure To
& Link to my My Blogs
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I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving my wife Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.

If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….ARCHIVEMEDICAL LINKSCANCER LINKSHOT LINKS< in the Sidebar.
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YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help you in ANY way. .

Regards,
Greg_L-W.

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Posted by: Greg Lance-Watkins
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#Canakinumab #Novartis study shows drug may halve cancer deaths and cut heart attack risks …

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#Canakinumab #Novartis study shows drug may halve cancer deaths and cut heart attack risks …

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Posted by:
Greg Lance – Watkins
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`Milestone´ study shows drug may halve cancer deaths and cut heart attack risks

An “exciting” new study has revealed a drug that could help reduce the risk of heart attacks and cut cancer deaths.

More than 10,000 patients took part in a trial using the anti-inflammatory Canakinumab, the results of which were presented at the European Society of Cardiology meeting in Barcelona, Spain.

The patients, all of whom had previously had a heart attack but had not been diagnosed with cancer, were treated with the drug once every three months, and monitored for up to four years.

The Canakinumab Anti-inflammatory Thrombosis Outcomes study, or CANTOS, showed a 15% reduction in the risk of heart attacks and strokes, and cancer deaths cut in half, the hospital where one of the lead authors is based said.

John Stilwell
 

John Stilwell

Dr Paul Ridker of Brigham and Women’s Hospital in Boston, said the study “represents a milestone in a long journey”, adding that the findings “usher in a new era of therapeutics”.

He said: “For the first time, we’ve been able to definitively show that lowering inflammation independent of cholesterol reduces cardiovascular risk.

“This has far-reaching implications. It tells us that by leveraging an entirely new way to treat patients – targeting inflammation – we may be able to significantly improve outcomes for certain very high-risk populations.”

The hospital said the reductions in risk were “above and beyond” those seen in patients who only took statins.

Statins
 

Statins

Dr Ridker said the study showed another way to prevent repeated heart attacks, through the use of anti-inflammatories.

He said: “In my lifetime, I’ve gotten to see three broad eras of preventative cardiology.

“In the first, we recognised the importance of diet, exercise and smoking cessation. In the second, we saw the tremendous value of lipid-lowering drugs such as statins. Now, we’re cracking the door open on the third era. This is very exciting.”

Gary Gibbons, director of the National Heart, Lung, and Blood Institute, said the results provided a platform on which to carry out further trials and research.

Stopping smoking, attending to diet and cutting down on alcohol are still the best primary steps to take (Jonathan Brady/PA)
 

Stopping smoking, attending to diet and cutting down on alcohol are still the best primary steps to take (Jonathan Brady/PA)

He said: “Although this trial provides compelling evidence that targeting inflammation has efficacy in preventing recurrent cardiovascular events, we look forward to findings from additional trials, such as the NHLBI-funded Cardiovascular Inflammation Reduction Trial, to further refine the best therapeutic strategies for preventing cardiovascular disease.”

In looking at the effects of the drug on cancer, Dr Ridker said the findings indicate “the possibility of slowing the progression of certain cancers” but said further research is required.

The study was funded by Novartis Pharmaceuticals.

To see the original of this article CLICK HERE
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Regards,
     Greg_L-W
Greg Lance-Watkins
.
 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving my wife Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.

If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….ARCHIVEMEDICAL LINKSCANCER LINKSHOT LINKS< in the Sidebar.
.
YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help you in ANY way. .

Regards,
Greg_L-W.

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Posted by: Greg Lance-Watkins
tel: 44 (0)1594 – 528 337
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