Life's Roller Coaster

If I'm missing, or not taking messages sorry – I'm more angry about letting my friends down than YOU will ever be at being let down! Unfortunately that is sometimes a side effect of Cancer! Mea Culpa: may I blame being short fused & grumpy on it too! My first symptoms presented in Nov-1998 – Follow The Trail on >DIARY of CANCER< Immediately Below!

Ever Minded At The Patchy Fog That Hampers Areas Of My Memory It Is Reassuring To Note Chemo Brain Is Now Proven …

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FORMATEver Minded At The Patchy Fog That Hampers Areas Of My Memory It Is Reassuring To Note Chemo Brain Is Now Proven … TO COPY …
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Posted by:
Greg Lance – Watkins
Greg_L-W

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Hi,

Chemo-brain IS real: Scientists discover how cancer treatments damage white matter to cause mental fog

  • More than half of cancer patients treated with chemo experience brain fog 
  • ‘Chemo-brain’ is a recognized phenomenon, but poorly understood
  • Stanford University researchers found that chemo affects three types of cells in the white matter 
  • They also discovered that a drug that may block and reverse these effects 

Scientists have finally begun to work out what exactly ‘chemo-brain’ is – and may have found a way to reverse the brain fog cancer treatment cause, a new study reveals. 

More than half of patients that receive chemotherapy report experiencing a cognitive fog for months and sometimes years after undergoing the intensive cancer treatment, but doctors haven’t really understood what causes this. 

A team of Stanford University scientists, however, have identified chemo’s effects on three different types of brain cells. 

They think that chemo causes a sort of arrested development for some brain cells and blocks the activity of cells that help ensure our brain cells are well-fed with nutrients because the drug triggers an overly-active immune response. 

In their experiments on mice, a drug to quell those immune cells helped to reverse chemo’s cognitive effects, giving the team hope that a treatment could be on the horizon.  

More than half of cancer patients who undergo chemotherapy experience 'brain-fog.' A new study reveals how the drug affects three types of brain cells - and a potential way to reverse it

 

More than half of cancer patients who undergo chemotherapy experience ‘brain-fog.’ A new study reveals how the drug affects three types of brain cells – and a potential way to reverse it

The advent of chemotherapy was a revolution in the treatment of cancer.

Around the time of World War II, the US military’s tests of mustard gas led to the discovery that compound based on mustard gas could combat some cancers. 

Soon thereafter, the predecessor to the now commonly-used methotrexate was discovered. 

Tumors grow when a DNA mutation allows cells to divide and multiply out of control. But methotrexate’s predecessor blocked that DNA from replicating, so it blocked cancer growth, too. 

Chemo’s roots in poisons and warfare are telling. Any chemotherapy is toxic to us – it’s just most toxic to carcinogenic cells.   

And our body responds accordingly. chemo often makes patients nauseous, unable to eat, makes them achy and tired and makes their hair fall out. 

Most worryingly to many cancer patients, chemo often comes with a decline in cognitive function that can last far longer than the treatments – or even the cancers, in some cases – themselves do. 

Chemo-brain was once dismissed as a wive’s tale. 

Even the world-renowned Mayo Clinic still calls the term ‘misleading’ and says that it is ‘unlikely that chemotherapy is the sole cause of concentration and memory problems in cancer survivors. 

We are at last beginning to understand what role it does play, however. 

The Stanford researchers focused on the neuron-supporting brain cells in the white matter. 

Three particular types seemed implicated in chem-brain: oligodendrocytes, astrocytes and microglia. 

Oligondendrocytes produce myelin, the coating that protects neurons. If these sheaths are damaged incomplete or missing, signals sent between brain cells are liable to interference. Like a radio, the signals might not come through clearly – or at all. 

Astrocytes lay important supporting roles for neurons, making sure that they are running smoothly and getting sufficient nutrition. 

And microglia are the brain’s own personal immune system. 

The researchers gave some mice with cancer chemotherapy, and left the others untreated.   

In the brains of those who had had chemotherapy, the myelin-producing cells never reached maturity, so they couldn’t produce sufficient myelin to protect the neurons. 

As a result, the mice moved more slowly, and had a harder time recalling elements of an environment that should  have been familiar to them. 

Even when they were injected with cells that would become oligondendrocytes from healthy mice, the cells got stuck in a state of arrested development in the chemo-treated mice’s brains, suggesting it was something about the toxicity of the brain environment that was interfering with this process. 

On the other hand, chemo seemed to supercharge the brain’s immune cells. The microglia were ‘persistently activated’ for at least six months after chemo was administered. 

They were on the defensive, behaving as if there was an infection or other pathogen to fight off, which likely meant prioritizing defensive action over other functions like nutrition. 

Indeed, the overactivity in the microglia interfered with the astrocytes, and the neurons struggled to get enough nutrition, which could be an additional cause of brain-fog. 

Remarkably, the Stanford researchers discovered that they could use a drug that attacked the microglia to restore the balance between them and the nutrient-feeding cells – reversing the cognitive effects of the chemo. 

‘The biology of this disease really underscores how important intercellular crosstalk is,’ lead study author and Stanford neurologist Dr Michelle Monje said. 

‘In addition to existing symptomatic therapies – which many patients don’t know about – we are now homing in on potential interventions to promote normalization of the disorders induced by cancer drugs. 

‘There’s real hope that we can intervene, induce regeneration and prevent damage in the brain.’   

To view the original article CLICK HERE

.
Regards,
     Greg_L-W
Greg Lance-Watkins
.
 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving my wife Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.

If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings. . Later in the sequence of my experiences with cancer you will note that I introduce some results and events most probably linked with cancer such as enlarged & damaged Prostate and a consequential Heart Attack leaving me with no right coronary artery! . I have also included numerous articles and anecdotes regarding health – primarily related to cancer, prostate and heart conditions – FYI! . Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar. . You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
.
YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help you in ANY way. .

Regards,
Greg_L-W.

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Posted by: Greg Lance-Watkins
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Should We Start Screening For #ColoRectal_Cancer Younger? #ACS thinks YES! …

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Should We Start Screening For #ColoRectal_Cancer Younger? #ACS thinks YES! …
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Posted by:
Greg Lance – Watkins
Greg_L-W

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Hi,

Illustration by Sydney Rae Hass for TIME
By Jamie Ducharme

May 30, 2018

 

Millions of Americans may book an extra doctor’s appointment this year, thanks to updated guidelines from the American Cancer Society (ACS).

The ACS is now recommending that adults at average risk of colorectal cancer begin regular screenings at age 45, rather than the previous standard of age 50. The change was informed by research from ACS scientists, who found last year that cancers of the colon and rectum are occurring at increasing rates among young and middle-aged adults. Studies have shown that roughly one in seven colon cancer patients is younger than 50.

People with a strong family history of colorectal cancers, a personal history of inflammatory bowel disease or certain other risk factors may need to begin testing even earlier than age 45, the ACS said. High-risk individuals may also need to get tested more often than other people. (The recommended frequency of tests varies depending on type; some stool tests, for example, should be completed annually, while a colonoscopy may only be needed once a decade.)

Screening for cancers and other chronic diseases can be a fraught topic, as experts often disagree about when these tests should begin. The U.S. Preventive Services Task Force recently changed its guidelines around mammograms, for example, and there’s argument about whether these tests, and those for other cancers, are effective at all.

Ultimately, when it comes to colorectal cancers, like most chronic diseases, all decisions about how, when and how frequently to screen should be based on personalized conversations between individuals and their physicians, the ACS said.

To view the original of this article CLICK HERE

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Regards,
     Greg_L-W
Greg Lance-Watkins
.
 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving my wife Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.

If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings. . Later in the sequence of my experiences with cancer you will note that I introduce some results and events most probably linked with cancer such as enlarged & damaged Prostate and a consequential Heart Attack leaving me with no right coronary artery! . I have also included numerous articles and anecdotes regarding health – primarily related to cancer, prostate and heart conditions – FYI! . Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar. . You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
.
YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help you in ANY way. .

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
.
Posted by: Greg Lance-Watkins
tel: 44 (0)1594 – 528 337
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A Kidney Condition Puts Melania Trump in the Hospital …

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A Kidney Condition Puts Melania Trump in the Hospital …
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Posted by:
Greg Lance – Watkins
Greg_L-W

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Hi,

firstly lets wish Melania Trump a speedy and full recovery, with no future kidney or related scares, a fervent wish I make for all who have such issues.

Kidney Condition Puts Melania Trump in the Hospital

Image
Melania Trump, the first lady, underwent a surgical procedure on Monday morning. CreditDoug Mills/The New York Times

 

WASHINGTON — Melania Trump underwent a medical procedure on Monday morning to treat what the White House called a “benign kidney condition” and was reported to be recovering without trouble at a military hospital outside the capital.

“The procedure was successful and there were no complications,” the White House said in a statement. “Mrs. Trump is at Walter Reed National Military Medical Center and will likely remain there for the duration of the week. The first lady looks forward to a full recovery so she can continue her work on behalf of children everywhere.”

President Trump spoke with Mrs. Trump on Monday morning before the procedure and later spoke with the doctor after it was over, according to a White House official who asked not to be identified describing the private communications. In the late afternoon, the president flew by helicopter to Walter Reed to visit the first lady for about an hour before returning to the White House.“Heading over to Walter Reed Medical Center to see our great First Lady, Melania,” Mr. Trump said on Twitter. “Successful procedure, she is in good spirits. Thank you to all of the well-wishers!”

The White House said Mrs. Trump, 48, underwent an embolization procedure. The Johns Hopkins Patients’ Guide to Kidney Cancer describes an arterial embolization as a procedure in which a special spongelike material is placed into an artery that supplies blood to the kidney. A thin tube catheter is inserted into a vessel in the leg and into the main vessel feeding the kidney.

Such a procedure would block the blood supply that feeds the kidney and might be used to stop bleeding from a benign tumor, a small aneurysm or to reverse the growth of such a tumor, according to specialists. The Johns Hopkins guide said it can also be used to make it easier for a surgeon to remove the kidney but is more frequently used to control symptoms for someone who cannot undergo surgery.

 

Vice President Mike Pence said on Monday that Mrs. Trump’s procedure was “long-planned,” citing her visit to Walter Reed as the reason Mr. Trump had sent him to represent the administration at a reception hosted by the Israeli Embassy to celebrate the 70th anniversary of Israeli independence.

The fact that Mrs. Trump will remain in the hospital for the rest of the week was unusual in the most typical cases, according to leading medical experts.

“It’s like literally an outpatient procedure,” said Dr. Eleanor D. Lederer, a professor at the University of Louisville School of Medicine and past president of the American Society of Nephrology. “You go in, you have it done, you lie in bed for a while to keep the blood vessel from bleeding and then you go home.”

Another doctor, however, said Mrs. Trump was probably being kept in the hospital longer because of her position. “That’s because she is the first lady,” said Dr. Jeffrey Cadeddu, a professor of urology and radiology at the University of Texas Southwestern Medical Center in Dallas. “If it was you, you’d be in and out in a day, I promise.”

Still, embolization kills some surrounding healthy kidney tissue, which causes swelling and pain as a patient recovers, so a longer stay could be helpful or necessary, doctors said.

The White House did not explain what led Mrs. Trump to seek treatment or whether the “benign kidney condition” meant she had a benign tumor or something else. Specialists said it could be that doctors had been monitoring a mass for a while and decided to act on it now because it had grown. Or they said it could be that she experienced symptoms of some sort, like noticing blood in the urine or experiencing back pain or stomach pain.

Doctors may also have discovered bleeding while conducting routine tests for other reasons.

Dr. Joseph A. Vassalotti, the chief medical officer at the National Kidney Foundation, said his guess was that Mrs. Trump had either a benign tumor known as an angiomyolipoma or a bleeding cyst. “It sounds like it was a benign tumor,” he said.

Dr. David G. Warnock, an emeritus professor of medicine at the University of Alabama at Birmingham and a past president of the kidney foundation, said doctors frequently perform an embolization if a biopsy or other diagnostic procedure causes bleeding.

“My list of benign conditions that you’d embolize is pretty short,” he said. “Ninety percent of them are to stop bleeding after some procedure like a kidney biopsy.”

But Dr. Joseph V. Bonventre, chief of the renal unit at Brigham and Women’s Hospital in Boston said that it was unlikely Mrs. Trump would have a biopsy on this type of tumor and that doctors probably decided to conduct the embolization procedure to prevent a benign tumor from growing by starving it of blood, and therefore oxygen.

“In general, you want to embolize it because you don’t want it to continue to get bigger and erode into the larger vessels of the kidney where it can cause significant bleeding,” he said. He added that embolizing in this case was “most likely a preventive thing.”

The procedure came just a week after Mrs. Trump formally kicked off a public campaign to encourage children to put kindness first in their lives, particularly on social media. She has generally maintained a low profile during her 16 months as first lady, focusing primarily on raising her son, Barron.

Mrs. Trump makes a point of leading a healthy lifestyle. In New York, she has said she would walk with ankle weights and eat seven pieces of fruit every day. “I live a healthy life, I take care of my skin and my body,” she told GQ in 2016. “I’m against Botox, I’m against injections; I think it’s damaging your face, damaging your nerves. It’s all me. I will age gracefully, as my mom does.”

The health of first ladies has long been a factor in White House life. Three first ladies died while living in the White House — Letitia Tyler (wife of John Tyler), Caroline Harrison (wife of Benjamin Harrison) and Ellen Wilson (wife of Woodrow Wilson) — and Andrew Jackson’s wife, Rachel, died between his election and inauguration.

Others have suffered serious ailments that, for much of the country’s history, were shrouded from the public. In recent decades, first ladies have been more open, although not in every instance. Betty Ford set the tone for modern times by being open about having a mastectomy to fight breast cancer. Following her example, Nancy Reagan also disclosed her own mastectomy, although she limited the details released.

Barbara Bush disclosed her Graves’ disease, a thyroid condition, while living in the White House. Her daughter-in-law, Laura Bush, however did not reveal that she had a skin cancer tumor removed from her shin until weeks later, deeming it “no big deal at the time.”

To view the original article CLICK HERE

Do note that a friend of mine who is a little older than Melania Trump recently had a nephrectomy on suspicion of cancer, the kidney was removed by hand assisted laprascopic surgery and two days later she went home and was back at work inside two weeks. She was fortunate that the biopsy on thesizeable tumor in the removed kidney it was found to be currently benign and no further medical action or treatment was required.

.
Regards,
     Greg_L-W
Greg Lance-Watkins
.
 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving my wife Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.

If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings. . Later in the sequence of my experiences with cancer you will note that I introduce some results and events most probably linked with cancer such as enlarged & damaged Prostate and a consequential Heart Attack leaving me with no right coronary artery! . I have also included numerous articles and anecdotes regarding health – primarily related to cancer, prostate and heart conditions – FYI! . Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar. . You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
.
YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help you in ANY way. .

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
.
Posted by: Greg Lance-Watkins
tel: 44 (0)1594 – 528 337
Calls from ‘Number Withheld’ phones Are Blocked

All unanswered messages are recorded.
Leave your name & a UK land line number & I will return your call.

‘e’Mail Address: Greg_L-W@BTconnect.com

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TWITTER: @Greg_LW

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#Stephen_Fry’s Own Words Regarding His Recent Diagnosis With #Prostate_Cancer & His Chosen Treatment …

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#Stephen_Fry’s Own Words Regarding His Recent Diagnosis With #Prostate_Cancer & His Chosen Treatment …
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Posted by:
Greg Lance – Watkins
Greg_L-W

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 .

Hi,

first may I wish Stephen Fry a speedy and full recovery from the actions he and his Oncology Consultant decided to take when he had been diagnosed to have Prostate Cancer.

Do listen to Stephen Fry’s story in his own words and if you need more information on Prostate Cancer just put >prostate cancer< in the >SEARCH BOX< at the top of the >Right Sidebar< on this web site and follow the links.

Here is a film of the Robotic operating machine Stephen Fry spoke of, it is commonly known as a Da Vinci Machine and is operated by a surgeon or trained operator remotely via a VDU:

.
Regards,
     Greg_L-W
Greg Lance-Watkins
.
 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving my wife Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.

If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings. . Later in the sequence of my experiences with cancer you will note that I introduce some results and events most probably linked with cancer such as enlarged & damaged Prostate and a consequential Heart Attack leaving me with no right coronary artery! . I have also included numerous articles and anecdotes regarding health – primarily related to cancer, prostate and heart conditions – FYI! . Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar. . You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
.
YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help you in ANY way. .

Regards,
Greg_L-W.

~~~~~~~~~~#########~~~~~~~~~~
.
Posted by: Greg Lance-Watkins
tel: 44 (0)1594 – 528 337
Calls from ‘Number Withheld’ phones Are Blocked

All unanswered messages are recorded.
Leave your name & a UK land line number & I will return your call.

‘e’Mail Address: Greg_L-W@BTconnect.com

Skype: GregL-W

TWITTER: @Greg_LW

DO MAKE USE of LINKS,
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I try to make every effort to NOT infringe copyrights in any commercial way & make all corrections of fact brought to my attention by an identifiable individual
.

Please Be Sure To
.Follow Greg_LW on Twitter.

Re-TWEET my Twitterings
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Delaying The Death Of Charlie Gard …

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Delaying The Death Of Charlie Gard …

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Posted by:
Greg Lance – Watkins
Greg_L-W

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 .

Hi,

I am pleased to note that the obscene point scoring of the likes of The Papacy, Donald Trump and others as they interfered with the treatment of Charlie Gard, for their own gain, contra the sound advice of medical experts and the center of excellence Great Ormond Street Children’s Hospital – Charlie Gard’s death will now be permitted with no further experimentation & artificial extension.

Common sense & common decency prevailed in the end though Charlie Gard has been dead, in real terms since December, sustained mechanically, with no knowledge of just what he was suffering, besides gross indignity!

 

demtrsnxuaev7io Britain USA 

A cruel and ignorant campaign

The agonising case of Charlie Gard, the 11-month old baby dying from a rare form of mitochondrial disease, is edging towards a no less agonising conclusion.

Today, his parents agreed that he should be transferred from Great Ormond Street hospital in London (GOSH) to a hospice to spend there his final period of life.

The hospice was a compromise. The parents have been fighting the plan for their baby’s end of life care just as they had fought the decision that he should no longer be kept alive. They wanted to bring Charlie home to die. The hospital refused to agree because of the difficulties of providing the particular ventilation and other procedures for Charlie at home, and the potential for causing him yet more distress or even causing him to die before he got home.

The court that has been attempting to arbitrate this heartbreaking dispute has set a deadline of noon tomorrow for the parents to find a team that can support Charlie for the days the parents want to spend with him at the hospice. Otherwise he will be taken off his life support shortly after being transferred.

The parents deserve only the most profound sympathy. Their unremitting rage at the hospital has to be seen in the context of mind-altering grief. In such a state, however, it is sometimes not possible to make decisions that really are in the best interests of their child. In this case, moreover, it is impossible to avoid the conclusion that their stress has been hugely compounded by one of the most cruelly ill-conceived campaigns of recent times.

The parents finally agreed to allow Charlie to die having seen from his most recent scan and the opinion of American neurologist Professor Michio Hirano, whose experimental nucleoside treatment (NBT) they hoped would save him, that any such treatment was hopeless. Yet in her emotional statement to the court Charlie’s mother Connie Yates implied that if he had been treated earlier he could have been saved.

Clearly, no-one can ever know if that might have been so. But what we do know is that at no stage was any credible evidence brought forward to show that Charlie’s brain damage was not irreversible, as the hospital told the parents it was months ago, so much so that any further treatment was futile. Nor was there ever any evidence during this time that Professor Hirano’s or any other treatment would ameliorate his condition.

The statement put out by the hospital after Ms Yates’s emotional words is worth reading in full. It addressed head on the key questions posed by the parents and their supporters: why not give Charlie at least the chance of further treatment? What did he have to lose? And if he had been treated months ago, would this terrible situation have been avoided?

In its answer, the hospital noted once again that no animal or human with Charlie’s precise disease had even been treated by NBT. After Charlie had suffered seizures before last Christmas, the entire treating team formed the view that Charlie had suffered irreversible neurological damage and that, as a result, any chance of benefit from this treatment had departed.

Charlie’s parents, however, refused to believe his brain was damaged. There lay the root of the problem. For do all these people demonstrating outside the court and shrieking that Great Ormond Street hospital were “murderers”, or writing ignorant and intemperate op-eds in the American media declaring that only the parents had the right to decide what was in the best interests of their child, really believe that parents know better than neurologists about damage that has been done to the brain?

The hospital statement contains two particularly devastating passages. The first leaves the reputation of Professor Hirano in shreds.

“Professor Hirano (“the Professor”), whose laboratory research has an international reputation, is very well known to the experts at GOSH and he communicated with them about NBT treatment for Charlie at the very end of December. In January, GOSH invited the Professor to come and see Charlie. That invitation remained open at all times but was not taken up until 18 July after being extended, once again, this time by the Court.

“When the hospital was informed that the Professor had new laboratory findings causing him to believe NBT would be more beneficial to Charlie than he had previously opined, GOSH’s hope for Charlie and his parents was that that optimism would be confirmed.”

That claim of new research evidence was why the parents returned to court and re-opened the case. The judge said he was eager to hear of this new evidence and hoped it would enable him to reverse his previous ruling. The GOSH statement, however, continues:

“It was, therefore, with increasing surprise and disappointment that the hospital listened to the Professor’s fresh evidence to the Court. On 13 July he stated that not only had he not visited the hospital to examine Charlie but in addition, he had not read Charlie’s contemporaneous medical records or viewed Charlie’s brain imaging or read all of the second opinions about Charlie’s condition (obtained from experts all of whom had taken the opportunity to examine him and consider his records) or even read the Judge’s decision made on 11 April.

“Further, GOSH was concerned to hear the Professor state, for the first time, whilst in the witness box, that he retains a financial interest in some of the NBT compounds he proposed prescribing for Charlie. Devastatingly, the information obtained since 13 July gives no cause for optimism. Rather, it confirms that whilst NBT may well assist others in the future, it cannot and could not have assisted Charlie.”

In other words, there never was any hope for Charlie – and the claim that
fresh research evidence provided some new hope was wholly without foundation and came from someone who had never even examined the child.

But here’s the really wicked thing about all this. The parents were reinforced in their refusal to accept this tragic situation, and the whole court process pointlessly prolonged, because of the pressure largely emanating from activists and media on the American political right (along with right-to-life campaigners) screaming that a baby was about to be killed by a socialised health care “death panel” enforced by the British government. This campaign led the parents to believe that such pressure could change the court’s mind. And so the parents were reinforced in their refusal to face reality.

The commentary emanating from America, however, was staggeringly ill-informed. The website American Thinker, for example, ran one hysterical piece after another. Thus the case represented “a perfect crystallization of the full heart and soul of socialized or ‘single payer’ health care”, a “tyrannically impersonal “medical system” in which “the individual human being is property of the State”.

“Little Charlie Gard appears to be under a death sentence courtesy of Great Ormond Street Hospital and the British Courts” in “a totalitarian state where the courts decide whether my child can live or die, where they can withhold medical treatment as and when they decide, where they can prevent treatment in another nation, where the rights of the individuals involved can be thrown on the floor and trashed like so much refuse”

…“the almost inhuman indifference to the plight of the parents by the Great Ormond Street Hospital, who insist that the parents should have no hope of improvement in their son and acquiesce in his death”…

“progressive death cult according to which individual lives are mere variables in an abstract calculus based on social utility and budgetary value.” And so on, and on.

On Liberty Unyielding, a writer decided that the case reflected the belief she thought was expressed by a British ethicist that “the authority of government over human life is itself a first principle, so inviolable that everything else must yield to it.”

Even the normally intelligent Wall Street Journal decried “a system that elevated a judge’s opinion about what was best for Charlie over loving parents. Few should be surprised, because the brutal reality is that when the state is responsible for nearly all health spending it inevitably takes responsibility for life and death decisions too.”

But this case had absolutely nothing to do with the state or the government. This was not Charlie’s parents v the state. This was Charlie’s parents v the medical profession, a conflict in which the courts were brought in as the dispassionate arbiter in the best interests above all of the sick child.

This was another thing the American commentators seemed incapable of grasping. In the US, the courts are highly politicised with judicial figures appointed by the state. But in Britain the courts are truly independent, representing law and justice. The state does not tell the British courts what to do; the British courts in fact hold the state to account. So the idea that the courts were enforcing state diktat in this case was totally ridiculous.

Nor had this anything to do with “socialised medicine” or the NHS system. This was purely a case where doctors were making decisions absolutely in line with medical ethics, which hold that causing a patient any pain or distress from treatment is only permissible if there is clear benefit to the patient from that treatment. In this case, there was not.

And this fact was reflected in the most devastating passage in the hospital’s statement.

“At the first hearing in Charlie’s case in March, GOSH’s position was that every day that passed was a day that was not in his best interests. That remains its view of his welfare. Even now, Charlie shows physical responses to stressors that some of those treating him interpret as pain and when two international experts assessed him last week, they believed that they elicited a pain response.

“In GOSH’s view there has been no real change in Charlie’s responsiveness since January. Its fear that his continued existence has been painful to him has been compounded by the Judge’s finding, in April, that since his brain became affected by RRM2B [his genetic disease] , Charlie’s has been an existence devoid of all benefit and pleasure. If Charlie has had a relationship with the world around him since his best interests were determined, it has been one of suffering.”

That is the most terrible point of all. Charlie may have been in pain and distress. That above all was the hospital’s fear; that above all weighed particularly heavily on the judge’s mind. If that was indeed so, then every day this case has dragged on has meant that this sick baby might have been caused yet more suffering.

If so, the parents in their great distress cannot be blamed. The people who should consider what harm they may have done here are all those who, through giving the parents such false hopes, so cruelly embedded them in their denial of reality.

Whether or not Great Ormond Street hospital was right or wrong in its diagnosis, its medical staff were only ever concerned with one thing: the best interests of their tiny patient. For this they have been subjected to vilification and death threats and portrayed as inhumane and murderers. This is unspeakable.

I write a great deal about the ideological bullying of the left, the lies published by left-wing media and the inhumanity and irrationality of so much allegedly progressive thinking. But I have never witnessed such concentrated ignorance, arrogance, stupidity and unthinking cruelty as has been displayed by the American political right over the tragic case of Charlie Gard.

The last word should be given to Great Ormond Street hospital:

“All of GOSH’s thoughts go with Charlie and his mother and father – the hospital wishes each of them peace in their hearts at the end of this day and each day to come”.

To view Melanie Phillips’ Original Article CLICK HERE
.
Regards,
     Greg_L-W
Greg Lance-Watkins
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‘Fingerprint’ in the blood is linked to prostate cancer risk …

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‘Fingerprint’ in the blood is linked to prostate cancer risk

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Hi,

‘Fingerprint’ in the blood is linked to prostate cancer risk

05 July 2017 | News, Science and research

Dr Travis leads a research project that we fund at the University of Oxford.

My current project is exploring a new field of research that has the potential to uncover ways of preventing prostate cancer through improved diet and lifestyle.

Prostate cancer is the most common cancer in British men, so this research is incredibly important and it would not be possible without the support of World Cancer Research Fund.

What the study found

This new area of research is known as metabolomics and it measures small molecules in the blood called metabolites.

Our study found that the levels of different metabolites that make up a man’s metabolic ‘fingerprint’ in the blood were linked with his risk of developing prostate cancer.

How does this relate to my daily life?

The levels of different metabolites present in someone’s blood are partly determined by diet and lifestyle. This means that the ‘fingerprint’ of metabolites in the blood could give us new insights into how diet and lifestyle can affect prostate cancer risk.

The next stage of the project will focus on working out precisely how diet and lifestyle factors can affect the pattern of metabolites in the blood. This will help us achieve our ultimate aim of fully understanding how diet and lifestyle can help prevent prostate cancer.

Making a difference

There is already strong evidence that maintaining a healthy weight is associated with a reduced risk of aggressive types of prostate cancer.

However, if more risk factors for prostate cancer are uncovered, this could help us prevent many more cases, particularly the more aggressive types.

To view the original article CLICK HERE

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Regards,
     Greg_L-W
Greg Lance-Watkins
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 Please Be Sure To
& Link to my My Blogs
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I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving my wife Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.

If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings. . Later in the sequence of my experiences with cancer you will note that I introduce some results and events most probably linked with cancer such as enlarged & damaged Prostate and a consequential Heart Attack leaving me with no right coronary artery! . I have also included numerous articles and anecdotes regarding health – primarily related to cancer, prostate and heart conditions – FYI! . Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar. . You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
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YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help you in ANY way. .

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Greg_L-W.

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Pioglitazone: Too often ending in Bladder Cancer? …

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Pioglitazone: Too often ending in Bladder Cancer? …
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Hi,

Pioglitazone: Too often ending in bladder cancer?

January 14, 2017 – Is there an increased risk of bladder cancer with pioglitazone-containing medicines? Some (most) drug regulatory agencies worldwide do think so. However, the actions taken vary considerably. The example of the French ANSM (L’Agence nationale de sécurité du médicament et des produits de santé en France) is at one end of the possibilities of actions on could take. In 2011 already, based on the results of  an extended epidemiological study (published in 2012) conducted in France which suggested an increased risk of bladder cancer with pioglitazone, the ANSM suspended the use of the pioglitazone-containing medicines (i.e., Actos and Competact) in France.

At the same time in 2011 when the American Food & Drug Administration (FDA) was also fully aware of this epidemiological study conducted in France, FDA resorted to a Safety Communication on June 15, 2011, which in fact was an update of an Safety Communication in 2010 on an “Ongoing Safety Review of Actos (pioglitazone) and Potential Increased Risk of Bladder Cancer After Two Years Exposure” only. Similarly, at the same time the European Medicines Agency (EMA) was in the process of reviewing all available data on pioglitazone-containing medicines use and re-analyze the risk / benefit ratio shortly, while Germany’s Federal Institute for Drugs and Medical Devices (BfArM) at least recommended not to start pioglitazone-containing medicines in new patients. Consequently, in very big markets worldwide, patients remained on pioglitazone-containing medicines and the associated risk for bladder cancer.

And here we go again: On December 12, 2016, FDA has concluded in a Drug Safety Communication, referring to an updated FDA-review of data indicating that there exist an increased risk of bladder cancer with pioglitazone-containing medicines, which currently include, in the US Actos, Actoplus Met, Actoplus Met XR, Duetact, and Oseni. The drug labels of these medicines already contain warnings about the risk of bladder cancer, and FDA has approved label updates to describe the additional studies reviewed.

The question remains if just analyzing data and adjusting drug labels by the FDA is sufficient to protect patients from the risks of getting bladder cancer. In the light of still additional and very serious adverse effects of, for example Actos, there arises the question if FDA should not simply ban pioglitazone-containing medicines and in doing so saving thousands of patients from suffering form bladder cancer. Bladder cancer definitively is no feat. Generally, protecting patients from unintended suffering brought about by medications should be at center stage not at FDA alone, but at all registration authorities worldwide. Whether that is really the case in context of pioglitazone is at least in doubt.

The fact that the manufacturer settles legal cases of patients (or their families) who have connected their bladder cancer condition with taking piaglitazone-containing medications for millions of dollars indicates that enormous economic interest are associated with these medicines. It it unlikely that the manufacturer pays these sums in favor of the individual patient who suffered and in acknowledgement of the sometimes fatal deficiencies of their product. Its seems more a measure to get the product out of sight of negative marketing and news.

To view the original of this article CLICK HERE

Regards,
Greg_L-W.

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