New target discovered for kidney cancer therapy

New target discovered for kidney cancer therapy
.

 Please Be Sure To

& Link to my My Blogs
To Spread The Facts World Wide

To Give Hope & Information

 .

Kidney and blader 1200 resolution 612KB
New target discovered
for kidney cancer therapy

Last updated: 12 November 2014 at 12am PST

Cancer / Oncology
Urology / Nephrology

Cincinnati Cancer Center (CCC) researchers have discovered that a membrane channel, Transient Receptor Potential Melastatin 3, or TRPM3, promotes growth of kidney cancer tumors, and targeting this channel therapeutically could lead to more treatments for a disease that currently has few treatment options.

A membrane channel is a family of proteins that allows the movement of ions, water or other solutions to pass through the membrane.

These findings were published in the journal Cancer Cell.

“Metastatic clear cell kidney cancer is largely incurable, and existing treatments for the disease are only minimally effective,” says Maria Czyzyk-Krzeska, MD, PhD, senior author of the study, member of the CCC and the University of Cincinnati (UC) Cancer Institute and professor in UC’s department of cancer biology. “Our team found a new target in kidney cancer known as TRPM3. TRPM3 is increased in 60 percent of kidney clear cell carcinomas where it promotes growth of tumors by stimulating intracellular pathways that initiate autophagy – a quality control process in cancer cells that also generates intracellular nutrients.

“During tumor growth, cancer cells become addicted to autophagy as a source of nutrients. Furthermore, autophagy contributes to chemotherapy resistance in kidney cancer. The new target we’ve identified regulates kidney cancer cell autophagy.”

The experiments were conducted using animal models, human cell cultures and tumor specimens. The researchers analyzed expression of the channel, its effect on tumor growth and on autophagy and how regulation of autophagy contributed to tumor growth.

“Our discovery of a TRPM3 stimulated network in the regulation of autophagy and kidney cancer growth could lead to use of the channel as a new actionable target in renal cancer. There are already FDA-approved TRPM3 inhibitors on the market, so this is quite promising,” Czyzyk-Krezeska says.

To view the original of this article  CLICK HERE
.
Regards,
Greg_L-W.
.
 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

.
If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings.
.
Thoughts, articles and comments will be in chronological order in the main blog and can be tracked in the >ARCHIVE< in the Left Sidebar.
.
You may find the TABS >MEDICAL LINKS< and also >CANCER LINKS< of help, also many of the links in articles and >HOT LINKS< in the Sidebar.
.
YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help in ANY way. .

Posted by: Greg Lance-Watkins

tel: 01594 – 528 337
Accuracy & Copyright Statement: CLICK HERE
Summary, archive, facts & comments on UKIP: http://UKIP-vs-EUkip.com
DO MAKE USE of LINKS & >Right Side Bar< & The Top Bar >PAGES<
Also:
Details & Links: http://GregLanceWatkins.com
UKIP Its ASSOCIATES & DETAILS: CLICK HERE
Views I almost Totally Share: CLICK HERE
General Stuff archive: http://gl-w.blogspot.com
General Stuff ongoing: http://gl-w.com
Health Blog. Archive: http://GregLW.blogspot.com
Health Blog. Ongoing: http:GregLW.com

TWITTER: Greg_LW

Enhanced by Zemanta
Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s