After KC drugs Tumours DO NOT Grow Faster

After KC drugs Tumours DO NOT Grow Faster
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Reassuring Evidence: Anticancer Drug Does Not Accelerate Tumor Growth After Treatment Ends

Studies in animals have raised concerns that tumors may grow faster after the anticancer drug sunitinib is discontinued.
But oncologists and physicists who collaborated to analyze data from the largest study of patients with kidney cancer convincingly demonstrate that such tumor acceleration does not occur in humans.
The findings, publishing online on Feb. 7th in the Cell Press journal Cell Reports, suggest that sunitinib does not cause lingering risks for patients after their treatment ends.
(Credit: Cell Reports, Blagoev et al.)

Feb. 7, 2013 — Studies in animals have raised concerns that tumors may grow faster after the anticancer drug sunitinib is discontinued. But oncologists and physicists who collaborated to analyze data from the largest study of patients with kidney cancer convincingly demonstrate that such tumor acceleration does not occur in humans. The findings, publishing online on February 7th in the Cell Press journal Cell Reports, suggest that sunitinib does not cause lingering risks for patients after their treatment ends.


“We were able to demonstrate that this applied across all patients and that those who had the greatest benefit from the drug while it was administered retained this benefit,” says senior author Dr. Tito Fojo, of the National Cancer Institute at the National Institutes of Health.

Sunitinib, which is approved around the world for the treatment of several different cancers, works by targeting proteins on the blood vessels that feed tumors. Animal studies have suggested that treatment with sunitinib may induce changes in tumor vessels or adaptations within tumors themselves that could promote cancer growth and spread.

When Dr. Fojo and his colleagues analyzed more than 10,000 data points from the pivotal randomized phase 3 clinical trial that led to sunitinib’s approval, the evidence clearly showed that no matter how long patients took sunitinib, it was not harmful, did not accelerate tumor growth, and did not shorten survival after treatment ended. During treatment, the drug slowed tumor growth and prolonged the patients’ survival.

“Last year, I was approached by two patients who had grave concerns about taking sunitinib due to an article conducted in animals. I realized that if clinical data exist that refute basic science, they must be published,” recalls Dr. Fojo.

The researchers’ findings indicate that sunitinib can benefit patients without altering tumor biology after the drug is stopped. “We hope this can be generalized to similar drugs but recognize that further studies will be needed,” says first author Dr. Krastan Blagoev of the National Science Foundation. “Nevertheless, other drugs also approved worldwide for a variety of cancers — including sorafenib, pazopanib, and axitinib — are similar to sunitinib, and this will give some reassurances that one need not expect things to get worse after such drugs are discontinued.”

To view the original article CLICK HERE
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Regards,
Greg_L-W.
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 Please Be Sure To
& Link to my My Blogs
To Spread The Facts World Wide To Give Others HOPE
I Have Been Fighting Cancer since 1997 & I’M STILL HERE!
I Have Cancer, Cancer Does NOT Have Me
I just want to say sorry for copping out at times and leaving Lee and friends to cope!
Any help and support YOU can give her will be hugely welcome.
I do make a lousy patient!

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If YOU want to follow my fight against Cancer from when it started and I first presented with symptoms in 1998 see The TAB at the Header of this Blog. called >DIARY of Cancer ….< just click and it will give you a long list of the main events in chronological order, many linked to specific blog postings.
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YOU are welcome to call me, minded that I am NOT medically trained, if you believe I can help in ANY way. .

Posted by: Greg Lance-Watkins

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